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(Recibido: 31.03.05)Tj
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(Aceptado: 18.04.05)Tj
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(C. M. Cabrera Morales)Tj
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(toneal, normalmente se presenta en chicos jvenes, y se caracteriza por la presencia de clulas pequeas e indi-)Tj
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[(fluorescente \(FISH\) no se encontr la translocacin t\(1)37(1)0(;22\))]TJ
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(\(p13;q12\).)Tj
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(Palabras clave)Tj
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(T)Tj
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[(umor desmoplsico de clulas pequeas y redondas. FISH. T)34.9(ranslocacin. EWS1. WT1.)]TJ
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(Oncologa, 2005; 28 \(5\):244-248)Tj
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(. Es ms frecuente su)Tj
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(redondas \()Tj
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[(desmoplastic small r)36.7(ound cell tumor)]TJ
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(agresividad)Tj
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(2)Tj
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(, recientemente descrita y reconocida)Tj
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(que afecta principalmente a nios y adultos)Tj
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(jvenes)Tj
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(, con una edad promedio de aparicin de 21)Tj
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(aos y con una elevada prevalencia en hombres)Tj
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0 Tw
(4)Tj
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(. Es)Tj
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(una neoplasia que afecta difusamente al peritoneo)Tj
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(abdominal o plvico, aunque se han descrito casos)Tj
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(en otras localizaciones con una frecuencia baja)Tj
T*
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(\(pleura, tnica )Tj
ET
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(vaginalis)Tj
ET
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q
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[(, SNC, hgado, ovario,)]TJ
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0.0049 Tc
0 Tw
(etc\))Tj
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0 Tc
(5)Tj
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0.005 Tc
0.0949 Tw
(. La histologa tpica se caracteriza por la pre-)Tj
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(sencia de nidos o trabculas de clulas tumorales)Tj
T*
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[(embebidos en un estroma fibroso. No es infrecuente)]TJ
T*
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(observar necrosis en el centro de los nidos de ma-)Tj
T*
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(yor tamao. Su principal caracterstica diagnstica)Tj
T*
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0.1238 Tw
(es la co-expresin de marcadores epiteliales, mus-)Tj
T*
0.005 Tc
0.1138 Tw
(culares, y neuronales)Tj
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0 Tc
0 Tw
(6)Tj
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0.005 Tc
0.1139 Tw
(, as como la presencia de la)Tj
-9.0478 -1.1818 TD
0.0481 Tc
0.0818 Tw
[(translocacin recproca t\(1)36.7(1;22\) \(p13;q12\) que)]TJ
T*
0.0564 Tc
0.0736 Tw
(afecta a los genes EWS1 \(gen del sarcoma de)Tj
T*
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0 Tw
[(Ewing\) y WT1 \(gen del tumor de W)39.9(ilms\))]TJ
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[(7,)-505(8)]TJ
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0 Tc
(.)Tj
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0.0427 Tw
(Presentamos el segundo caso de tumor desmopl-)Tj
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0.0225 Tw
(sico de clulas pequeas y redondas de rin descri-)Tj
T*
0.1241 Tw
(to en la literatura)Tj
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0 Tw
(9)Tj
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0.1241 Tw
(, en el que por tcnicas de FISH)Tj
-7.4741 -1.1818 TD
0.0073 Tc
0.1177 Tw
(no se ha encontrado la translocacin caracterstica)Tj
T*
0 Tc
0 Tw
(de este tipo de tumores.)Tj
ET
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(Caso clnico)Tj
ET
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[(Paciente de 20 aos de edad que acude a ur)17.8(gen-)]TJ
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0.0139 Tc
0.1111 Tw
(cias, con dolor lumbar y fiebre. Al paciente se le)Tj
T*
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0.0933 Tw
(realizan urocultivos, hemocultivos, y estudio de)Tj
T*
0 Tc
0.0926 Tw
[(marcadores tumorales \(pruebas que resultan negati-)]TJ
T*
0.118 Tw
[(vas\), por tomografa axial computerizada \(T)79.8(AC\) se)]TJ
T*
0.0205 Tw
(le detecta una masa tumoral que afecta al polo supe-)Tj
T*
-0.0001 Tc
0.0526 Tw
[(rior del rin derecho \(Fig. 1\). T)34.8(r)-0.1(as lo cual se reali-)]TJ
T*
0 Tc
0 Tw
[(za la reseccin quirr)17.8(gica del tumor)54.9(.)]TJ
0.9767 -22.4545 TD
0.0608 Tw
[(La pieza de reseccin quirr)17.8(gica estaba constitui-)]TJ
-1.0012 -1.1818 TD
0.0512 Tw
(da por una masa tumoral de 14 cm de dimetro ma-)Tj
T*
0.0108 Tc
0.1142 Tw
[(yor)39.8(, con infiltracin del polo superior y segmento)]TJ
T*
0 Tc
0.0052 Tw
(medio renales, y afectacin del seno y sistema pielo-)Tj
T*
0.0028 Tc
0.1222 Tw
(calicial. Se observ presencia de invasin vascular)Tj
ET
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q
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(Oncologa, 2005; 28 \(5\):244-248)Tj
ET
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q
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0 Tw
(39)Tj
ET
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Q
q
1 i
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0 822 m
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/F2 1 Tf
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0 Tw
(Summary)Tj
ET
Q
q
1 i
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0 822 m
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BT
/F1 1 Tf
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[(Desmoplastic small round cell tumor is a rare disease consisting of a form of peritoneal surface malignancy)]TJ
-0.9767 -1.2727 TD
0.001 Tc
0.124 Tw
[(usually af)17.8(fecting young males, composed of relatively small and undif)17.6(ferentiated cells with a high nuclear)19.6(-)]TJ
T*
0.0038 Tc
0.1212 Tw
[(cytoplasmic ratio. The co-expression of epithelial, muscular and neuronal antigens distinguishes this entity)]TJ
T*
0.0019 Tc
0.123 Tw
[(from other small round cell tumors. The t\(1)36.8(1;22\)\(p13;q12\) translocation is a recurrent characteristic of this)]TJ
T*
0 Tc
0.0153 Tw
[(type of tumor)54.9(. However)39.8(, we report a new case of desmoplastic small round cell tumor of the kidney af)17.9(fecting a)]TJ
T*
0 Tw
[(20 year old male where the t\(1)36.9(1;22\)\(p13;q12\) is absent. )]TJ
ET
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/F2 1 Tf
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/GS1 gs
-0.0001 Tc
0 Tw
(Key words: )Tj
ET
Q
q
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0 822 m
W n
0.015 822.015 540.99 -822 re
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BT
/F1 1 Tf
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0 0 0 1 k
/GS1 gs
0 Tc
0 Tw
[(Desmoplastic small round cell tumor)54.9(. FISH. T)34.9(ranslocation. EWS1. WT1.)]TJ
ET
0 0 0 0 k
285.06 340.24 231.77 -173.31 re
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285.06 340.24 231.77 -173.31 re
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/GS1 gs
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233.494 0 0 174.3753 284.11 166.3947 cm
/Im1 Do
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BT
/F1 1 Tf
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0 Tw
(Figura 1. TAC abdominal: masa hipodensa en rin derecho. )Tj
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(linftica tumoral en el tejido renal y grasa adyacen-)Tj
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0.0034 Tc
0.1216 Tw
(te. Metstasis medular de glndula suprarrenal, in-)Tj
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(Mediante la realizacin de tcnicas de inmunohis-)Tj
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(toqumica sobre secciones de parafina con diferentes)Tj
T*
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(anticuerpos monoclonales \(Dako\) se encontr el si-)Tj
T*
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(guiente patrn de tincin compatible con un tumor)Tj
T*
0.0854 Tw
(desmoplsico de clulas pequeas y redondas: cito-)Tj
T*
0.0098 Tw
(queratinas 8, 18 y 19 \(+\), protena cida fibrilar glial)Tj
T*
-0.0001 Tc
0.0828 Tw
(\(-\), desmina \(+\) \(Fig. 2\), vimentina \(+\), sinaptofisi-)Tj
T*
0.0242 Tw
[(na \(+\), cromogranina \(-\), actina \(dbilmente +\), y S-)]TJ
T*
0 Tc
0 Tw
(100 \(dbilmente +\).)Tj
0.9767 -1.1818 TD
0.0091 Tw
(Se realiz igualmente el estudio citogentico de la)Tj
22.5094 36.6364 TD
0.0076 Tc
0.1174 Tw
[(translocacin t\(1)36.9(1;22\) \(p13;q12\) que implica a los)]TJ
0 -1.1818 TD
0.0157 Tc
0.1093 Tw
(genes EWS1 y WT1 mediante hibridacin )Tj
ET
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0 0 0 1 k
/GS1 gs
0.0157 Tc
0.1093 Tw
(in situ)Tj
ET
Q
q
1 i
0 822 541 -822 re
0 822 m
W n
0.015 822.015 540.99 -822 re
W n
BT
/F1 1 Tf
11 0 0 11 285.1176 436.9843 Tm
0 0 0 1 k
/GS1 gs
0.0055 Tc
0.1194 Tw
(fluorescente \(FISH\), para ello se utiliz el kit LSI)Tj
0 -1.1818 TD
0.0004 Tc
0.1245 Tw
(EWSR1 \(22q12\) Dual Color Break Apart Rearran-)Tj
T*
-0.0001 Tc
0.0537 Tw
[(gement Probe \(VYSIS\). El cual est constituido por)]TJ
T*
0 Tc
0.0897 Tw
(una mezcla de dos sondas que flanquean completa-)Tj
T*
0.0374 Tw
(mente el locus del gen EWS1 \(Fig. 3\), la sonda ms)Tj
T*
0.1149 Tw
(centromrica est marcada con )Tj
ET
Q
q
1 i
0 822 541 -822 re
0 822 m
W n
0.015 822.015 540.99 -822 re
W n
BT
/F3 1 Tf
11 0 0 11 428.8016 371.9843 Tm
0 0 0 1 k
/GS1 gs
-0.0001 Tc
0 Tw
(Spectrum-Orange)Tj
ET
Q
q
1 i
0 822 541 -822 re
0 822 m
W n
0.015 822.015 540.99 -822 re
W n
BT
/F1 1 Tf
11 0 0 11 511.6176 371.9843 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0 Tw
(y)Tj
-20.5909 -1.1818 TD
0.002 Tc
0.123 Tw
(las ms telomrica con )Tj
ET
Q
q
1 i
0 822 541 -822 re
0 822 m
W n
0.015 822.015 540.99 -822 re
W n
BT
/F3 1 Tf
11 0 0 11 394.2733 358.9843 Tm
0 0 0 1 k
/GS1 gs
0.0019 Tc
0 Tw
[(Spectrum-Gr)36.7(een)]TJ
ET
Q
q
1 i
0 822 541 -822 re
0 822 m
W n
0.015 822.015 540.99 -822 re
W n
BT
/F1 1 Tf
11 0 0 11 466.8659 358.9843 Tm
0 0 0 1 k
/GS1 gs
0.002 Tc
0.123 Tw
(. Como re-)Tj
-16.5226 -1.1818 TD
0 Tc
0.0896 Tw
(sultado de este diseo cualquier translocacin en la)Tj
T*
0.0749 Tw
(que est implicado el locus EWS1 produce la sepa-)Tj
T*
0.0637 Tw
(racin de la seal de fusin rojo-verde en una seal)Tj
T*
0.0112 Tw
(roja y otra verde. El patrn observado en nuestro ca-)Tj
T*
0.0714 Tw
(so se corresponde con el patrn de normalidad, con)Tj
T*
0.0143 Tc
0.1106 Tw
(presencia de dos seales de fusin roja-verde por)Tj
T*
0 Tc
0.0816 Tw
(cada clula tumoral \(Fig. 4\), confirmando por tanto)Tj
T*
0 Tw
(la ausencia de translocacin en el paciente.)Tj
0.9767 -1.1818 TD
-0.012 Tc
0.0241 Tw
[(El paciente fue tratado con tres ciclos de CA)129(V)129.1(,)0( cua-)]TJ
-1.0012 -1.1818 TD
0.0225 Tc
0.0904 Tw
(tro ciclos de Ifosfamida/VP-16, y posteriormente)Tj
T*
0.0021 Tc
0.1109 Tw
(CTX, ADR, y VCR. Como resultado de este trata-)Tj
T*
-0.0071 Tc
0.1201 Tw
[(miento no se detecta infiltracin tumoral en mdula)]TJ
T*
-0.0009 Tc
0.1139 Tw
[(sea. Sin embar)17.8(go posteriormente se le detect por)]TJ
T*
0 Tc
0 Tw
(T)Tj
0.519 0 TD
-0.012 Tc
0.0043 Tw
[(AC reaparicin del tumor y metstasis heptica. T)35.1(ras)]TJ
-0.519 -1.1818 TD
0.0273 Tw
(lo cual no se produce respuesta al tratamiento y el pa-)Tj
T*
-0.0056 Tc
0.1186 Tw
(ciente fallece a los dos aos del diagnstico inicial.)Tj
ET
Q
q
1 i
0 822 541 -822 re
0 822 m
W n
0.015 822.015 540.99 -822 re
W n
BT
/F2 1 Tf
14 0 0 14 284.8479 111.9843 Tm
0 0 0 1 k
/GS1 gs
-0.0002 Tc
0 Tw
(Discusin)Tj
ET
Q
q
1 i
0 822 541 -822 re
0 822 m
W n
0.015 822.015 540.99 -822 re
W n
BT
/F1 1 Tf
11 0 0 11 295.5912 85.9843 Tm
0 0 0 1 k
/GS1 gs
0.0035 Tc
0.1215 Tw
(El trmino tumor de clulas pequeas y redon-)Tj
-0.9767 -1.1818 TD
-0.0001 Tc
0.0024 Tw
(das \()Tj
ET
Q
q
1 i
0 822 541 -822 re
0 822 m
W n
0.015 822.015 540.99 -822 re
W n
BT
/F3 1 Tf
11 0 0 11 310.8269 72.9843 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0.0022 Tw
[(small r)36.9(ound cell tumor)]TJ
ET
Q
q
1 i
0 822 541 -822 re
0 822 m
W n
0.015 822.015 540.99 -822 re
W n
BT
/F1 1 Tf
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0 0 0 1 k
/GS1 gs
0 Tc
0.0023 Tw
(\) describe a un grupo de)Tj
-11.4694 -1.1818 TD
0.119 Tw
(tumores malignos altamente agresivos formado por)Tj
ET
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0 J 0 j 0.5 w 10 M []0 d
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517.12 719.95 l
S
0 0 0 0 k
26.77 788 490.35 -56 re
f
Q
q
1 i
0 822 541 -822 re
0 822 m
W n
0.015 822.015 540.99 -822 re
W n
BT
/F2 1 Tf
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0 0 0 1 k
/GS1 gs
-0.0001 Tc
0 Tw
(C. M. Cabrera Morales)Tj
ET
0 0 0 0 k
26.77 48 24.01 -17.01 re
f
Q
q
1 i
0 822 541 -822 re
0 822 m
W n
0.015 822.015 540.99 -822 re
W n
BT
/F1 1 Tf
10 0 0 10 26.7705 33.1601 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0 Tw
(40)Tj
ET
0 0 0 0 k
27.02 691.36 231.77 -173.32 re
f
Q
q
1 i
27.02 691.36 231.77 -173.32 re
W* n
/GS1 gs
q
233.494 0 0 174.8721 26.07 517.3479 cm
/Im2 Do
Q
Q
q
1 i
0 822 541 -822 re
0 822 m
W n
0.015 822.015 540.99 -822 re
W n
0 0 0 1 K
0 J 0 j 0.5 w 10 M []0 d
/GS1 gs
27.02 691.36 231.77 -173.32 re
S
0 0 0 0 k
26.77 510.44 232.27 -26.96 re
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BT
/F1 1 Tf
9 0 0 9 26.7705 504.2817 Tm
0 0 0 1 k
0 Tc
0.0213 Tw
(Figura 2. Tcnica de inmunohistoqumica positiva para desmina)Tj
1.0753 -1.1948 TD
-0.0001 Tc
0 Tw
(\(HE x200\).)Tj
ET
0 0 0 0 k
27.02 474.36 231.77 -150.72 re
f
Q
q
1 i
27.02 474.36 231.77 -150.72 re
W* n
/GS1 gs
q
232.847 0 0 151.9049 26.65 323.1251 cm
/Im3 Do
Q
Q
q
1 i
0 822 541 -822 re
0 822 m
W n
0.015 822.015 540.99 -822 re
W n
0 0 0 1 K
0 J 0 j 0.5 w 10 M []0 d
/GS1 gs
27.02 474.36 231.77 -150.72 re
S
0 0 0 0 k
26.77 317.46 232.27 -71.96 re
f
BT
/F1 1 Tf
9 0 0 9 26.7705 311.3032 Tm
0 0 0 1 k
0 Tc
0.0075 Tw
(Figura 3. Estructura gnica de la regin cromosmica 22q12. La)Tj
1.0753 -1.1948 TD
0.0156 Tc
0.1093 Tw
(sonda naranja marcada con Spectrum-Orange de ~500 Kb)Tj
T*
0.0401 Tc
0.0849 Tw
(flanquea la regin 5 del gen EWS1, la sonda verde de)Tj
T*
0.0034 Tc
0.1216 Tw
(~1.100 kb marcada con Spectrum-Green flanquea la regin)Tj
T*
0 Tc
0 Tw
(3 del gen.)Tj
ET
0 0 0 0 k
285.1 691.36 231.77 -150.72 re
f
Q
q
1 i
285.1 691.36 231.77 -150.72 re
W* n
/GS1 gs
q
233.494 0 0 152.0195 284.15 540.0705 cm
/Im4 Do
Q
Q
q
1 i
0 822 541 -822 re
0 822 m
W n
0.015 822.015 540.99 -822 re
W n
0 0 0 1 K
0 J 0 j 0.5 w 10 M []0 d
/GS1 gs
285.1 691.36 231.77 -150.72 re
S
0 0 0 0 k
284.85 534.46 232.27 -61.96 re
f
BT
/F1 1 Tf
9 0 0 9 284.8479 528.3032 Tm
0 0 0 1 k
0 Tc
0.0909 Tw
(Figura 4. Clulas tumorales del paciente en estado de interfase)Tj
1.0753 -1.1948 TD
0.125 Tw
(marcadas con el kit LSI EWSR1 Dual Color, que muestran)Tj
T*
0.0455 Tw
(dos seales de fusin rojo-verde por clula, indicativo de au-)Tj
T*
0 Tw
(sencia de cualquier translocacin que afecte al gen EWS1.)Tj
ET
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q
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0 822 541 -822 re
0 822 m
W n
0.015 822.015 540.99 -822 re
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0 0 0 0 k
/GS1 gs
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Q
q
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0 822 541 -822 re
0 822 m
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0.015 822.015 540.99 -822 re
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/F1 1 Tf
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0 0 0 1 k
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0.0048 Tc
0.1202 Tw
(clulas pequeas e indiferenciadas con ncleos hi-)Tj
0 -1.1818 TD
0.0202 Tc
0.1048 Tw
(percromticos redondos u ovales, nucleolos poco)Tj
T*
0.0023 Tc
0.1227 Tw
(evidentes y citoplasma escaso)Tj
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0 Tc
0 Tw
(4)Tj
11 0 0 11 166.4883 657.9843 Tm
0.0023 Tc
0.1227 Tw
(. Este grupo incluye)Tj
-12.705 -1.1818 TD
-0.0001 Tc
0.0258 Tw
[(el sarcoma de Ewing \(ES\), neuroepitelioma perifri-)]TJ
T*
0 Tc
0.0938 Tw
(co, neuroblastoma perifrico, rabdomiosarcoma, tu-)Tj
T*
0.0003 Tc
0.1247 Tw
(mor desmoplsico de clulas pequeas y redondas,)Tj
T*
0.0032 Tc
0.1218 Tw
(linfoma, leucemia, osteosarcoma de clulas peque-)Tj
T*
0.0196 Tc
0.1054 Tw
[(as, carcinoma de clulas pequeas, y melanoma)]TJ
T*
0 Tc
0.0154 Tw
(maligno, entre otros)Tj
6.6 0 0 6.6 115.3483 583.6143 Tm
0 Tw
(10)Tj
11 0 0 11 121.9484 579.9843 Tm
0.0153 Tw
[(. Para la distincin entre sarco-)]TJ
-8.6559 -1.1818 TD
0.0378 Tw
(mas, carcinomas, y linfomas se emplean tres marca-)Tj
T*
0.0296 Tw
(dores muy tiles: el antgeno pan-leucocitario CD45)Tj
T*
0.0117 Tc
0.1132 Tw
(\(especfico de linfomas\), citoqueratinas \(presentes)Tj
T*
0 Tc
0.0811 Tw
(en tumores de origen epitelial y algunos sarcomas\),)Tj
T*
0.0931 Tw
(y el filamento intermedio vimentina \(presente en la)Tj
T*
0.0055 Tw
(mayora de los tumores mesenquimales y en algunos)Tj
T*
-0.0001 Tc
0 Tw
(carcinomas\). )Tj
0.9767 -1.1818 TD
0 Tc
0.0884 Tw
(El tumor desmoplsico de clulas pequeas y re-)Tj
-0.9767 -1.1818 TD
0.0161 Tc
0.1089 Tw
(dondas es una entidad distinguible dentro de este)Tj
T*
0 Tc
0.0687 Tw
(grupo por su comportamiento histoqumico y por la)Tj
T*
0.1123 Tw
(presencia de abundante estroma desmoplsico)Tj
6.6 0 0 6.6 234.4713 440.6143 Tm
-0.0614 Tc
0 Tw
(11)Tj
11 0 0 11 240.6659 436.9843 Tm
0 Tc
0.1123 Tw
(. La)Tj
-19.4484 -1.1818 TD
0.0179 Tc
0.1071 Tw
(distincin de este tumor se logra mediante inmu-)Tj
T*
0 Tc
0.0316 Tw
(nohistoqumica para marcadores epiteliales \(querati-)Tj
T*
0.0179 Tw
(na, antgeno de la membrana citoplasmtica de clu-)Tj
T*
0.0032 Tc
0.1218 Tw
(las epiteliales\), neuronales \(enolasa neuro-especfi-)Tj
T*
0 Tc
0.1043 Tw
(ca\), y musculares \(desmina\). Igualmente la translo-)Tj
T*
0.0057 Tc
0.1193 Tw
[(cacin recproca t\(1)36.9(1;22\) \(p13;q12\) que implica al)]TJ
T*
0 Tc
0.0226 Tw
(producto del gen EWS1 y WT1 es una caracterstica)Tj
T*
0 Tw
(recurrente y especfica de este tipo de sarcomas)Tj
6.6 0 0 6.6 235.9077 336.6143 Tm
(7, 8)Tj
11 0 0 11 245.8078 332.9843 Tm
(. )Tj
-18.9392 -1.1818 TD
0.008 Tc
0.1169 Tw
(Los reordenamientos cromosmicos que afectan)Tj
-0.9767 -1.1818 TD
0 Tc
0.1248 Tw
(al gen EWS1 localizado en la regin cromosmica)Tj
T*
0.0812 Tw
[(22q12 \(Fig. 3\) se han observado en diferentes tipos)]TJ
T*
-0.0001 Tc
0.0035 Tw
(de tumores)Tj
6.6 0 0 6.6 75.3363 284.6143 Tm
0 Tc
0 Tw
(12)Tj
11 0 0 11 81.9364 280.9843 Tm
0.0001 Tc
0.0033 Tw
(. Aproximadamente el 90% de las trans-)Tj
-5.0185 -1.1818 TD
0.019 Tc
0.106 Tw
(locaciones que afectan al gen EWS1 producen la)Tj
T*
0.0173 Tc
0.1077 Tw
[(translocacin t\(1)36.8(1;22\) \(q24;q12\) que yuxtapone a)]TJ
T*
0 Tc
0.0905 Tw
(EWS1 con el gen FLI1)Tj
6.6 0 0 6.6 132.1332 245.6143 Tm
0 Tw
(13)Tj
11 0 0 11 138.7333 241.9843 Tm
0.0906 Tw
(. La segunda translocacin)Tj
-10.1818 -1.1818 TD
0.001 Tc
0.124 Tw
(ms frecuente implica a EWS1 y ERG)Tj
6.6 0 0 6.6 204.5063 232.6143 Tm
0 Tw
(14)Tj
11 0 0 11 211.1199 228.9843 Tm
0.0009 Tc
0.124 Tw
(, represen-)Tj
-16.7624 -1.1818 TD
0 Tc
0.093 Tw
(tando la translocacin con WT1 un porcentaje muy)Tj
T*
0.0439 Tc
0.0811 Tw
(pequeo. El gen WT1 codifica una protena de)Tj
T*
0.0067 Tc
0.1183 Tw
(unin al DNA que acta como un factor de trans-)Tj
T*
0 Tc
0.0099 Tw
(cripcin, y que igualmente interviene durante el pro-)Tj
T*
0.0219 Tw
(ceso de diferenciacin y desarrollo del sistema geni-)Tj
T*
0.0062 Tc
0.1188 Tw
(tourinario y tejidos mesoteliales)Tj
6.6 0 0 6.6 173.7393 154.6143 Tm
0 Tw
(15)Tj
11 0 0 11 180.422 150.9843 Tm
0.1188 Tw
(. WT1 es un gen)Tj
-13.9717 -1.1818 TD
0 Tc
0.1059 Tw
(supresor de tumor que participa en el desarrollo de)Tj
T*
0 Tw
[(un subgrupo de tumores de W)39.8(ilms)]TJ
6.6 0 0 6.6 177.5105 128.6143 Tm
(15)Tj
11 0 0 11 184.1106 124.9843 Tm
(.)Tj
-13.3304 -1.1818 TD
0.025 Tc
0.1 Tw
(En el caso clnico presentado, el estudio de la)Tj
-0.9767 -1.1818 TD
0 Tc
0.0398 Tw
(translocacin especfica presente en la gran mayora)Tj
T*
0.0455 Tw
(de tumores desmoplsicos de clulas pequeas y re-)Tj
T*
0.0123 Tc
0 Tw
(dondas)Tj
6.6 0 0 6.6 58.7053 76.6143 Tm
(16)Tj
11 0 0 11 69.5927 72.9843 Tm
0.1127 Tw
(investigado mediante la tcnica de FISH)Tj
-3.8963 -1.1818 TD
0 Tc
0.0656 Tw
(result ser negativo, revelando la ausencia de trans-)Tj
23.4616 56.7273 TD
0.0291 Tw
(locacin en el paciente \(Fig. 4\). Por lo tanto este ca-)Tj
0 -1.1818 TD
0.0155 Tw
(so raro hay que incluirlo dentro del pequeo porcen-)Tj
T*
0.1224 Tw
(taje de tumores desmoplsicos de clulas pequeas)Tj
T*
0.0098 Tc
0.1152 Tw
[(y redondas con ausencia de translocacin t\(1)37(1;22\))]TJ
T*
-0.0001 Tc
0 Tw
(\(p13;q12\))Tj
6.6 0 0 6.6 328.1876 635.6143 Tm
0 Tc
(16)Tj
11 0 0 11 334.7877 631.9843 Tm
(.)Tj
ET
Q
q
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0 822 m
W n
0.015 822.015 540.99 -822 re
W n
BT
/F2 1 Tf
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0 0 0 1 k
/GS1 gs
-0.0001 Tc
0 Tw
(Conclusin)Tj
ET
Q
q
1 i
0 822 541 -822 re
0 822 m
W n
0.015 822.015 540.99 -822 re
W n
BT
/F1 1 Tf
11 0 0 11 295.5539 566.9843 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0.0884 Tw
(El tumor desmoplsico de clulas pequeas y re-)Tj
-0.9767 -1.1818 TD
0.0575 Tw
(dondas constituye un pequeo porcentaje dentro del)Tj
T*
0.0052 Tc
0.1198 Tw
(grupo de los sarcomas, que comparte con ellos un)Tj
T*
0 Tc
0.021 Tw
(origen histolgico incierto y que presenta caracters-)Tj
T*
0.0076 Tc
0.1174 Tw
(ticas histoqumicas definidas. Si bien la transloca-)Tj
T*
0.0018 Tc
0.1232 Tw
[(cin t\(1)36.8(1;22\) \(p13;q12\) que fue primeramente des-)]TJ
T*
0 Tc
0.0513 Tw
(crita por Gerald y col.)Tj
6.6 0 0 6.6 383.8784 492.6143 Tm
0 Tw
(17)Tj
11 0 0 11 393.7933 488.9843 Tm
0.0513 Tw
(como caracterstica distinti-)Tj
-9.9075 -1.1818 TD
0.0126 Tw
(va est presente en la gran mayora de los casos has-)Tj
T*
0.0137 Tc
0.1113 Tw
(ta ahora publicados)Tj
6.6 0 0 6.6 375.6488 466.6143 Tm
0 Tw
(16)Tj
11 0 0 11 382.4302 462.9843 Tm
0.1113 Tw
(, est ausente en el caso que)Tj
-8.8745 -1.1818 TD
0 Tc
0.1137 Tw
[(presentamos. Pudiendo existir otras alteraciones ci-)]TJ
T*
0.0014 Tc
0.1236 Tw
(togenticas que puedan tener relevancia en ese pe-)Tj
T*
0 Tc
0 Tw
(queo porcentaje de casos restantes.)Tj
9 0 0 9 355.783 361.2309 Tm
(Correspondencia:)Tj
0 -1.1948 TD
-0.0001 Tc
(Dra. C. M. Cabrera)Tj
T*
(Hospital Universitario Virgen de las Nieves)Tj
T*
0 Tc
(Servicio de Anatoma Patolgica)Tj
T*
(Edificio de Gobierno - 4 Planta)Tj
T*
-0.0001 Tc
(Avenida Fuerzas Armadas, 2)Tj
T*
0 Tc
-0.0001 Tw
(E-18014 Granada)Tj
T*
0 Tw
(E-mail: mcabrm@fundacionhvn.org)Tj
ET
0 0 0 1 K
0 J 0 j 0.5 w 10 M []0 d
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517.08 719.95 l
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0 0 0 0 k
26.73 788 490.35 -56 re
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0 822 541 -822 re
0 822 m
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0.015 822.015 540.99 -822 re
W n
BT
/F2 1 Tf
10 0 0 10 382.1097 734.168 Tm
0 0 0 1 k
/GS1 gs
0 Tc
-0.0001 Tw
(Oncologa, 2005; 28 \(5\):244-248)Tj
ET
0 0 0 0 k
493.07 48 24.01 -17.01 re
f
Q
q
1 i
0 822 541 -822 re
0 822 m
W n
0.015 822.015 540.99 -822 re
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BT
/F1 1 Tf
10 0 0 10 507.0804 33.1601 Tm
0 0 0 1 k
/GS1 gs
0 Tc
0 Tw
(41)Tj
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517.08 389 l
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