Abstract

GUERRERO GONZALEZ, Enrique; REYES VALDIVIA, Andrés; OCANA GUAITA, Julia  and  GANDARIAS ZUNIGA, Claudio. Update on biomarkers for early detection of intestinal ischemia. Angiología [online]. 2023, vol.75, n.2, pp.78-84.  Epub May 01, 2023. ISSN 1695-2987.  https://dx.doi.org/10.20960/angiologia.00425.

Intestinal ischemia associates high mortality rates, mainly due to a delay in diagnosis. Although computed tomography angiography (CTA) remains a sensitive and specific tool, it usually takes quite long until it is done, due to an unspecific clinical presentation. In this time lapse, intestinal ischemia may progress to an irreversible stage with signs of systemic failure. The acquisition of precise and early detection biomarkers for the disease would shorten the time to diagnosis and hence its associated mortality. It is acknowledged that those molecules which have been classically used-lactate amongst them-do not have a proper diagnostic capacity. Nevertheless, the D stereoisomer of lactate and procalcitonin have shown high sensitivity for detection of ischemic colitis after open aortic surgery, while D-dimer measurement is recommended to rule out acute mesenteric ischemia in patients with abdominal pain. Other molecules with a potential for diagnostic yield are intestinal fatty acid binding protein (i-FABP) and glucagon-like peptide-1 (GLP-1), still under investigation.

Keywords : Intestinal ischaemia; Mesenteric ischaemia; Ischaemic colitis; Biomarkers; D-lactate; I-FABP; GLP-1.

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