Abstract

CRUZ GUERRA, Nicolás Alberto. Outcomes of maximal androgen blockade in prostate cancer patients at health area with type 2 reference hospital (1^st part). Quality of life: application of the EORTIC QLQ-C30 instrument. Arch. Esp. Urol. [online]. 2009, vol.62, n.6, pp.431-459. ISSN 0004-0614.

Objectives: To analize the influence that maximal androgen blockade (MAB) exerts on quality of life in patients from the health area of Zamora diagnosed of prostate adenocarcinoma between 2000-2005. Methods: Basal, 12-month, 24-month and 36-month application of the health-related quality of life measurement instrument EORTC QLQ-PR25 to the population sample (n= 111), as well as a control sample (n= 100). We performed a comparative study of the outcomes between groups; between various time measurements in MAB patients; and inter-categories/ intervals of some variables in patients with hormonal deprivation therapy (third year of follow-up). Results: Cognitive and symptomatic fields were affected in patients with MAB at some specific time points. No field showed a significant constant worsening through the period of study for hormonally deprivated patients. A recovery is seen in the sociofamiliar field. Less academic level in MAB patients represents a distinguishing factor leading to worse outcomes in the healthrelated quality of life parameters analyzed here. Conclusions: There is a negative initial repercussion of MAB on quality of life, although tinged according to the different fields studied.

Keywords : Prostate cancer; Hormonal therapy; Quality of life.

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