Abstract

LIVI, L. et al. Organ-confined prostate cancer: treatment with high doses of radioterapy. (Intensity Modulated Radiotherapy). Actas Urol Esp [online]. 2007, vol.31, n.6, pp.611-616. ISSN 0210-4806.

Purpose: To report toxicity and local control in patients with localized prostate cancer, treated with high dose radiotherapy. Materials and methods: The records of 100 consecutive patients with clinically localized prostate cancer treated between june 2003 and may 2006 were reviewed. They received 80 Gy to the target volume with a biphasic technique (3DCRT + IMRT). The median pretreatment PSA was 9. The median follow-up time was 12 months. Results: Eighteen (18%) developed acute Grade 2 rectal toxicity, and no patient experienced acute grade 3 or higher rectal symptoms. Forty-four (44%) developed acute Grade 2 urinary symptoms while 34% of the patients experienced no GU symptoms (Grade 0) during treatment. Three patients (3%) developed late rectal toxicity grade 2 and eight patients (8%) experienced late urinary toxicity grade 2; any patients experienced more severe symptoms. We recorded biochemical relapse in two patients, both had poor prognostic factors at initial diagnosis of prostate cancer. Conclusions: The data demonstrate the feasibility and safety of high dose radiotherapy for patients with localized prostate cancer and provide a proof that this method allow safe dose escalation with low severe toxicities to the normal tissues.

Keywords : Intensity modulated radiotherapy treatment; Prostate cancer; Rectal toxicity; Radiotherapy.

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