Abstract

MONTOLIU GARCIA, A. et al. Tolerance of prostate biopsy with use of local anesthesia and benzodiazepines: a randomized, prospective study. Actas Urol Esp [online]. 2010, vol.34, n.1, pp.43-50. ISSN 0210-4806.

Introduction: Prostate biopsy is an uncomfortable procedure, and attempts are therefore being constantly made to try and decrease biopsy-related pain. Materials and methods: A randomized, prospective study including 160 procedures was designed. Inclusion criteria were: first biopsy, PSA < 15 ng/mL, and age under 75 years. Patients were randomized into 4 groups. Group A was the control group, while group B received intracapsular anesthesia (8 mL of 2% lidocaine), group C 5 mg of oral clorazepate dipotassium one hour before biopsy, and group D both local anesthesia and clorazepate. Each patient completed a questionnaire including three 10-point visual analog scales for pain immediately after the procedure and 30 minutes later. Results: Mean pain scores were 5.17 (group A), 1.72 (group B), 2.43 (group C), and 0.88 (group D) in the first questionnaire, and 1.71, 0.25, 0.75 and 0.35 respectively in the second questionnaire. Statistically significant differences were found in the ANOVA test. Group comparisons showed the following: 1. A vs B: statistically significant di fferences in both questionnaires (p = 0.006 and 0.011). 2. A vs C: a significant di fference was found in the first questionnaire (0.051), but not in the second (0.012). 3. A vs D: significant di fferences in both questionnaires (0.001 and 0.010). No statistically significant differences were seen in both questionnaires (0.825 and 0.685) when benzodiazepines where added to local anesthesia (B vs D). Conclusion: Use of benzodiazepines as a single method to decrease biopsy-related pain is not warranted.

Keywords : Prostate cancer; Prostate biopsy; Pain; Local anesthesia; Benzodiazepines.

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