Abstract

MEJIA, N. et al. Chronic kidney disease-mineral and bone disorder: a complex scenario. Nefrología (Madr.) [online]. 2011, vol.31, n.5, pp.514-519. ISSN 1989-2284.

The chronic kidney disease-bone and mineral disorders (CKD-MBD) represents a dinamic area of research. Recently, new factors such as FGF-23 have been added to the classic list of regulators of bone metabolism, which include calcium, phosphorus, PTH and calcitriol. Vascular calcification, one of the most important complication of CKD-MBD is regulated by a complex variety of promoters and inhibitors. The relationship between vascular calcification, bone loss and mortality, together with the existence of likely common signaling pathways are subject of interesting investigations.

Keywords : CKD-MBD; Vascular calcification; FGF-23; Bone demineralization; Secondary hyperparathyroidism.

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