Abstract

HOOMAN, Nakysa et al. Carotid artery function in children with idiopathic nephrotic syndrome. Nefrología (Madr.) [online]. 2013, vol.33, n.5, pp.650-656. ISSN 1989-2284.  https://dx.doi.org/10.3265/Nefrologia.pre2013.May.12036.

Background: Nephrotic patients are prone to atherosclerosis in consequence of frequent exposures to hyperlipidemia, hypertension, and immunosuppressive drugs. Objectives: We studied the carotid parameters as early indicators of atherosclerosis in children with nephrotic syndrome. Methods: Between 2008 and 2011, 51 children with history of nephrotic syndrome enrolled in the study. The inclusion criteria were: idiopathic nephrotic syndrome with normal serum complement, at least one year after initiation of disease, glomerular filtration rate more than 20mL/min/1.73m², age over two years old at the time of study. Seventy-five healthy sex-age-matched children considered as a control group. Carotid function parameters and left ventricular mass index were studied in nephrotic children. Results: Steroid sensitive, resistant, and dependent nephrotic syndrome included one-third each. The mean carotid intima-media thickness (mm) in nephrotic children was 0.42 (±.14) while the mean cIMT in controls was 0.37 (±.08) (p-value <.05). After log transformation, General Linear Multivariate analysis revealed significant difference of carotid intima-media thickness in nephrotic patients (p-value <.001). Subsequently, the factor that influenced on cIMT was duration of disease (P<.05). One-half of nephrotic children who had echocardiography, showed left ventricular hypertrophy. It was correlated with carotid stiffness and systolic hypertension (P<.05). Conclusions: Carotid intima-media thickness was thicker in nephrotic children. Carotid parameters were influenced by duration of disease and hypertension.

Keywords : Nephrotic Syndrome; Idiopathic; Child; Hypertrophy; Left Ventricular; Carotid Intima- Media Thickness.

        · abstract in Spanish     · text in English     · English ( pdf )