Abstract

FARRIOL, M. et al. Preoperative chemotherapy and total parenteral nutrition in colon cancer. Nutr. Hosp. [online]. 2006, vol.21, n.3, pp.303-306. ISSN 1699-5198.

Aim: The objetive of this study was to determine the effect of TPN after surgery in patients with colon carcinoma and preoperative chemotherapy. Material and method: The study included 27 patients, 16 men and 11 women, with a mean age of 62.1 ± 11.2 years. The patients were divided into two groups accordingto whether they had undergone chemotherapy (Group A; n = 11) or not (Group B, control; n = 16) prior to surgery. Almost two thirds of the patients were in stage III of the disease. Among those receiving this treatment,60% were given 5-fluorouracil plus leucovorin at a dose of 5.5 ± 2.7 cycles/patient and the others received different regimens. TPN was established early with a mean of 11.7 ± 9.2 days. The clinical and nutritional assessment was performed before surgery and at the end of TPN administration. Results: The mean body mass index (BMI) was 24.1 ± 2.2 kg/m². Comparison between the groups before the start of TPN showed statistically significant differences in red blood cell and platelet counts (P = .013 and P = .02, respectively). These differences had disappeared at completion of TPN, suggesting that this treatment can reverse the hematological changes induced by chemotherapy. Conclusion: In patients who receive chemotherapy before surgery and in whom TPN it was indicated the combination of these two treatments could be beneficial.

Keywords : Colon carcinoma; Parenteral nutrition; Chemotherapy.

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