Abstract

MARCHENA YGLESIAS, P. J. et al. Acute reactives and markers of inflammation in venous thromboembolic disease: clinical and evolution outcomes. An. Med. Interna (Madrid) [online]. 2006, vol.23, n.3, pp.105-110. ISSN 0212-7199.

Objective: To assess the association of acute reactants and interleukin 6 and 8 (IL-6 & IL-8) at diagnosis of venous thromboembolic disease (VTD) and clinical outcome. Methods: 100 patients were diagnosed of VTD by image tests. Acute reactants (C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), fibrinogen), D-dimer and IL-6 and IL-8 we measured at the moment of diagnosis. We made a 12 month follow-up of these patients to notice any clinical evolution outcomes (recurrences, bledding, postphlebitic syndrome, death). Results: IL-6 was increased in 9 patients and IL-8 in 3. The risk factors, time to diagnosis and pulmonary embolism rate were similar in both interleukin groups (normal and high levels). Fibrinogen levels were significantly increased in high IL-6 group (585 ± 179 vs. 485 ± 154 mgr/dl; p=0.05). During follow-up there were 5 deaths, 3 recurrences, 11 bleedings and 43 postphlebitic syndromes. Normal ESR level was associated to postphlebitic syndrome (17.8 ± 14.5 vs. 31.4 ± 27.4 mm/1st h; p=0.016). Patients who had high levels of IL-6 had worse survival than these with normal levels (p = 0.015). Conclusion: IL-6, ESR, and CPR at diagnosis of VTD could be useful to identified patients with higher risks of death and postphlebitic syndrome during the first year after diagnosis.

Keywords : Interleukin 6; Interleukin 8; Acute reactants; D-dimer; Venous thromboembolic disease.

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