Abstract

KHOSRAVI SHAHI, P.; CASTILLO RUEDA, A. del  and  PEREZ MANGA, G.. Neoplastic angiogenesis. An. Med. Interna (Madrid) [online]. 2008, vol.25, n.7, pp.366-369. ISSN 0212-7199.

Neoplastic angiogenesis is an essential process in the progressive growth of neoplasms and the production of metastasis. Angiogenesis consists of a series of linked and sequential steps that ultimately leads to the development of a neovascular blood supply to the tumor mass. VEGF has got an essential role in neoplastic angiogenesis, therefore it is an important target in the treatment of neoplasms. Bevacizumab, a humanized monoclonal antibody, inhibits VEGF, and may also improve the delivery of chemotherapy to the tumor mass. Multi-kinase ihibitors (sorafenib and sunitinib) are orally administered small-molecules, that inhibit different receptors (essentials in the neoplastic angiogenesis), such as the VEGFR or PDGFR. These agents are useful in the treatment of advanced renal-cell carcinoma, and are under investigation in several tumors.

Keywords : Cancer; VEGF; Bevacizumab; Sorafenib; Sunitinib.

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