Abstract

VINUESA-SILVA, J.M. et al. Conjuntival hyperemia with the use of a fixed combination of latanoprost/timolol: systematic review and meta-analysis of clinical trials. Arch Soc Esp Oftalmol [online]. 2009, vol.84, n.4, pp.199-207. ISSN 0365-6691.

Purpose: To asses the association of conjuntival hyperemia with the use of a fixed combination of latanoprost/timolol, through a systematic review and meta-analysis of clinical trials in patients with glaucoma. Methods: A systematic review of published clinical trials of latanoprost/timolol and other competitors was conducted in Medline, Embasse and Cochrane Controlled Clinical Trials Register, between 2000 and 2007. Statistical analysis included calculation of the odds ratio (OR) with its 95% confidence interval (CI) using the fixed effects model of Mantel-Haenszel and the random effects model of Der Simonian and Laird. To assess the heterogeneity between trials the Cochran Q test and the I² rate were calculated. The conjuntival hyperemia rates obtained were compared with the Chi-square test. Results: A total of 8 clinical trials comparing latanoprost/timolol fixed combination with different therapeutic options were found. As trial heterogeneity was moderate (Q: 14.64; df=7; p=0.041; I²= 52.2%) a random effects model was used. The final OR was 0.47 (CI 95%: 0.24-0.90); p = 0.024. The total conjuntival hyperemia incidence was 2.9% in the latanoprost/timolol group and 7.0% for the competitors (p< 0.0001). Conclusions: The use of a fixed combination of latanoprost/timolol is associated with a significant reduction (53%; CI 95%: 10%-76%) in the development of conjuntival hyperemia against the other compared options for the treatment of glaucoma.

Keywords : Conjuntival hyperemia; glaucoma; latanoprost; timolol; meta-analysis.

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