Abstract

SORRENTI-PIREZ, Natalia; FOSSATI-COLA, Santiago  and  FOSSATI, Gonzalo. Experimental preliminary study in rats: use of platelet rich plasma in the treatment of acute injuries of peripheral nerves. Cir. plást. iberolatinoam. [online]. 2016, vol.42, n.2, pp.131-140. ISSN 1989-2055.

Background and Objectives. Considering the social and laboral importance acquired by peripheral nerve injuries and the serious and permanent motor, sensory and vegetative damage leading to sequels, any therapeutic effort to improve the results of nerve repair represents a positive step in the overall management of this condition. Although a technically perfect suture was made, we never achieved repopulate the distal segment with the same amount of axons. This makes seeking alternatives to enhance nerve regeneration. Among the emerging therapies, the use of platelet rich plasma (PRP) has a beneficial effect on nerve repair. Until now, studies have focused on the use of PRP in grafts or guardians interposed between the ends and have not paid attention in its application in direct suture. Methods. We studied 8 Wistar rats with severed damage of both sciatic nerves: in one nerve suture was applied PRP and the other sutured nerve was taken as case control. In a second stage, both nerve biopsy was performed at different times and fixed with a lipophilic fluorophore which stains regenerated fibers. Controls were taken in 2 groups: 40 days and 60 days. Index sciatic nerve was calculated. Results. The nerves treated with PRP presented a break through in the recovery of nerve function as measured by functional tests and confirmed by histological study of the nerve. Conclusions. The results indicate a physiological process stimulating nerve repair using PRP.

Keywords : Neural injury; Peripheral nerves; Platelet rich plasma; Growth factors; Functional recovery.

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