Abstract

ANDRES, R.; AMARO, J.  and  BASCONES, A.. Interleukin 18, A new factor in the pathogenesis of the periodontal disease. Avances en Periodoncia [online]. 2006, vol.18, n.2, pp.91-100. ISSN 2340-3209.

Periodontal disease is an inflammatory, chronic and infectious process,where the tooth support tissues get lost.There is an agreement that bacteria are responsible for the beginning and support of the disease. It is believed that the type of individual immune response, is responsible for the periodontal destruction degree. It is thought that an immune response regulated by antibodies would produce a larger tissue destruction, due to the hyperstimulation of the immune system. While cellular immune response would be more protective with periodontal tissues. In this paper,we suggest that interleukin 18 (IL-18), as an interferon gamma inductor,would favor the cellular immune response development, allowing a more efficient bacterial elimination, reducing the periodontal tissue damage.

Keywords : Interleukin 18; ICE; Th1; Th2; Interferon-g; apoptosis.

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