Abstract

SEISDEDOS ELCUAZ, R. Prevention of recurrent pancreatitis in lipoprotein lipase deficiency with antioxidant therapy. Rev. OFIL·ILAPHAR [online]. 2020, vol.30, n.1, pp.73-74.  Epub Jan 18, 2021. ISSN 1699-714X.  https://dx.doi.org/10.4321/s1699-714x2020000100019.

Hypertriglyceridemia due to lipoprotein lipase deficiency (LPL) is a rare disease associated with recurrent pancreatitis. Evidence suggests that inflammation of the pancreas could be related to damage by free radicals. Bibliography supports the use of antioxidants in its prevention, specifically the combination of selenium, L-methionine, ascorbic acid and tocopherol.

The following is the case of a patient with hypertriglyceridemia associated with low LPL activity with recurrent pancreatitis. From the age of 23, he begins to suffer episodes of recurrent acute pancreatitis (more than 14 admissions). It highlights a period of 4 and a half years in which there is no episode coinciding with the cessation of smoking.

At the age of 46, he starts antioxidants treatment. For this purpose, master formula L-methionine and ascorbic acid capsules 480/120 mg and selenomethionine capsules 600 mg were performed. Throughout the treatment the values of triglycerides remain stable. Since then he has not presented any diagnosis of acute pancreatitis.The association between hypertriglyceridemia and pancreatitis is well known, and the latter is potentially fatal. In our case, the combination of antioxidants is shown as a safe and effective option. In view of the results and studies, it also seems essential to avoid smoking. In addition, it is essential to highlight the importance of the master formula. However, efficacy and safety studies with a greater number of patients and for a longer period of time would be recommended.

Keywords : Pancreatitis; hypertriglyceridemia; antioxidants; lipoprotein lipase; hiperlipidemias.

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