Abstract

GIL-SIERRA, MD  and  BRICENO-CASADO, MP. Multidisciplinary clinical management of complex patient with Crohn's disease and paradoxical psoriasiform reaction. Rev. OFIL·ILAPHAR [online]. 2022, vol.32, n.4, pp.403-405.  Epub Oct 23, 2023. ISSN 1699-714X.  https://dx.doi.org/10.4321/s1699-714x20220004000016.

Crohn's disease is an inflammatory disease of any part of the gastrointestinal tract. This pathology can present systemic and extra-intestinal manifestations. Biological drugs are used in patients with moderate-severe Crohn's disease refractory to previous therapies. Paradoxical psoriasiform reactions have been associated with biological treatments with an anti-tumor necrosis factor (antiTNF α) mechanism, such as adalimumab. On the other hand, ustekinumab has been described as an effective therapeutic alternative with a favorable safety profile in patients with comorbidities and/or hypersensitivity reactions to other drugs. The multidisciplinary collaboration of different healthcare professionals allows the identification of infrequent adverse events –such as paradoxical psoriasiform reaction– and therapeutic optimization of complex patients. This case describes the clinical and therapeutic experience of a multidisciplinary collaboration in a complicated patient diagnosed with Crohn's disease and a paradoxical psoriasiform reaction secondary to adalimumab.

Keywords : Ustekinumab; comorbidity; adverse reaction; psoriasiform reaction.

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