Abstract

ALONSO, G.  and  VARSAVSKY, M.. Osteomalacia in a young adult. Rev Osteoporos Metab Miner [online]. 2016, vol.8, n.2, pp.82-86. ISSN 2173-2345.

Cases of hypophosphatemic osteomalacia respond to various causes, both genetic and acquired. Some variants of mesenchymal tumors produce inappropriate amounts of fibroblast growth factor 23 (FGF-23), a mediator which induces renal phosphate loss. The biochemical picture is characterized by hypophosphatemia, decreased tubular reabsorption of phosphates, low or inappropriately normal serum calcitriol and high or unusually normal levels of FGF-23 plasma. This paraneoplastic syndrome is called tumor-induced or oncogenic osteomalacia. There are a limited series of published cases, although it has been increasingly accepted in recent years. Diagnosis may be complex given its low incidence, the difficulties in localizing the tumors and heterogeneity in histopathologic interpretation. Complete surgical removal has healed, but there may be recurrences whereas phosphorus and calcitriol oral supplements offer alternative medical treatment.

Keywords : hypophosphatemia; oncogenic osteomalacia; fibroblast growth factor 23; phosphaturic mesenchymal tumor.

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