Abstract

HERNANDEZ-COLINA, Marian  and  TORO GARCIA, Grisel Del. Cytotoxicity of 1-O-undecylglycerol in human breast cells by Real Time Cell Analysis. Ars Pharm [online]. 2016, vol.57, n.2, pp.63-66. ISSN 2340-9894.  https://dx.doi.org/10.30827/ars.v57i2.4963.

Aim: To study the effect of 1-O-undecylglycerol on the proliferation of human breast cancer cells MCF-7 and 184B5 normal breast cells. Methods: Real time following of both cell lines was performed, by Real Time Cell Analyzer. Appropriated cell density was selected, and cells were treated with two concentrations of 1-O-undecylglycerol for 48 hours. Cell index slopes were compared in each experiment. Results: 1-O-undecylglycerol induced significant reduction of MCF-7 cell viability, and was less cytotoxic on 184B5 cells with 75µM. At 150µM was cytotoxic for both lines, but cell index slope of breast cancer cells was negative. Conclusion: 1-O-undecilglicerol could be a candidate for future studies in in vivo models of breast cancer, and for further experiments about the mechanism involved in this effect.

Keywords : alkylglycerols; RTCA; MCF-7; 184B5.

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