Abstract

LUNA-SANCHEZ, Shirley; CAMPO BALSA, María Teresa del; MAHILLO FERNANDEZ, Ignacio  and  ESTEBAN MORENO, Jaime. Evolution of QuantiFERON^®-TB Gold in Tube (QFT-GIT) positive result and associated features from health care workers with latent tuberculosis infection in a tertiary hospital. Rev Asoc Esp Espec Med Trab [online]. 2016, vol.25, n.4, pp.220-229. ISSN 3020-1160.

The Interferon Gamma release assays complement or replace the tuberculin skin test (TST) for diagnosis of latent tuberculosis infection (LTBI), but are currently in controversy due to its reversions possibility. Our goal is to describe the evolution of QuantiFERON^®-TB Gold in Tube (QFT-GIT) following a positive result in healthcare workers with LTBI and possible related factors to the persistence, or not, of the result in a period of six years. We analyzed data from 46 workers, 60.9% of them women, the most common groups were nurses, doctors and nursing assistants, 32.6% of them belonged to considered high risk departments, and 26% reported previous chemoprophylaxis. We found 32.6% QFT-GIT reversions and less significant reversion risk in relation to a higher result of TST in millimeters, without significant relation between reversions and chemoprophylaxis. It is important to continue researching to resolve questions related to possible QFT-GIT reversions.

Keywords : Healthcare workers; QuantiFERON TB-Gold in Tube; latent tuberculosis infection; Interferon-gamma release assays.

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