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Gaceta Sanitaria

versión impresa ISSN 0213-9111

Resumen

VALCARCEL-NAZCO, Cristina et al. Cost-effectiveness of universal childhood vaccination against hepatitis A in Spain: a dynamic approach. Gac Sanit [online]. 2023, vol.37, 102292.  Epub 03-Mayo-2023. ISSN 0213-9111.  https://dx.doi.org/10.1016/j.gaceta.2023.102292.

Objective:

To evaluate the cost-effectiveness of infant universal vaccination against hepatitis A in Spain.

Method:

Using a dynamic model and decision tree model, a cost-effectiveness analysis was performed to compare three vaccination strategies against hepatitis A: non-vaccination strategy versus universal childhood vaccination of hepatitis A with one or two doses. The perspective of the study was that of the National Health System (NHS) and a lifetime horizon was considered. Both costs and effects were discounted at 3% per year. Health outcomes were measured in terms of quality adjusted life years (QALY) and the cost-effectiveness measure used was the incremental cost-effectiveness ratio (ICER). In addition, deterministic sensitivity analysis by scenarios was performed.

Results:

In the particular case of Spain, with low endemicity for hepatitis A, the difference in health outcomes between vaccination strategies (with 1 or 2 doses) and non-vaccination are practically non-existent, terms of QALY. In addition, the ICER obtained is high, exceeding the limits of willingness to pay from Spain (€22,000-25,000/QALY). The deterministic sensitivity analysis showed that the results are sensitive to the variations of the key parameters, although in no case the vaccination strategies are cost-effective.

Conclusions:

Universal infant vaccination strategy against hepatitis A would not be a cost-effective option from the NHS perspective in Spain.

Palabras clave : Cost-benefit analysis; Hepatitis A vaccines; Mass vaccination; Infant; Child; Spain.

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