SciELO - Scientific Electronic Library Online

 
vol.37 número2Contenido en electrolitos de medicamentos de uso parenteral autorizados por el Ministerio de Sanidad y ConsumoMedida de la mejora continua en la seguridad del paciente oncológico índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google

Compartir


Farmacia Hospitalaria

versión On-line ISSN 2171-8695versión impresa ISSN 1130-6343

Resumen

CASTILLO, I.  y  GRUPO DE ESTUDIO ESPANOL DEL USO COMPASIVO DE LENALIDOMIDA EN MIELOFIBROSIS et al. Effectiveness and safety of lenalidomide in myelofibrosis patients: a case series from the Spanish compassionate use program. Farm Hosp. [online]. 2013, vol.37, n.2, pp.135-142. ISSN 2171-8695.  https://dx.doi.org/10.7399/FH.2013.37.2.375.

Objective: Myelofibrosis (MF) is a chronic myeloproliferative neoplasm (CMPN) characterized by clonal proliferation of the pluripotent hematopoietic germinal cell, fibrosis, and bone marrow angiogenesis, and with extra medullary hematopoiesis. Lenalidomide is an immunomodulatory and antiangiogenic agent that has shown clinical benefit in MF patients in several phase II clinical trials. In this work, we present the results of the retrospective assessment of a series of 32 patients diagnosed with MF that received treatment with lenalidomide within the Spanish program of hospital compassionate use. Method: Multicenter, retrospective study of a case series of MF patients receiving compassionate treatment with lenalidomide. Results: We gathered information on 32 MF patients that were treated with lenalidomide at 17 Spanish hospitals. The mean age was 68 years (range, 50-83), 72% males. Twentysix (81%) patients had intermediate-high risk according to Dupriez's prognostic score. In 16 patients, the daily dose scheduled was 10 mg/day for 21 days in 28-day cycles; the remaining patients received lower doses or other regimes. In 29 out of 32 patients, response assessment was available. Two patients had complete clinical and hematologic response and 14 had partial response. The most common adverse events observed were neutropenia (56%), thrombocytopenia (50%), and anemia (40%). Conclusions: Continuous treatment with lenalidomide is active in MF patients pretreated heavily. Lenalidomide-induced myelosuppression and other associated toxicities are manageable with dose adjustments.

Palabras clave : Myelofibrosis; Compassionate use; Neoplasms myeloproliferative; Lenalidomide.

        · resumen en Español     · texto en Español     · Español ( pdf )

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons