Resumo

SEVILLANO, Ángel M. et al. Anakinra induces complete remission of nephrotic syndrome in a patient with familial mediterranean fever and amyloidosis. Nefrología (Madr.) [online]. 2016, vol.36, n.1, pp.63-66. ISSN 1989-2284.  https://dx.doi.org/10.1016/j.nefro.2015.06.026.

Renal amyloidosis is one of the most severe complications of familial Mediterranean fever (FMF). Colchicine has reduced the incidence of this complication, which now only appears in untreated, under-treated and resistant patients, but it is usually ineffective in patients with advanced amyloidosis. Here we report a patient with FMF and biopsy-proven amyloidosis who presented with nephrotic syndrome despite colchicine treatment. Anakinra (an interleukin-1β inhibitor) was started and a dramatic complete remission of nephrotic syndrome was observed in the following months. Anakinra can be an effective treatment for FMF patients with severe secondary amyloidosis.

Palavras-chave : Familial Mediterranean fever; Amyloidosis; Colchicine; Anakinra.

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