Resumo

PINHEIRO VOLP, A. C.; MIRANDA HERMSDORFF, H. H.  e  BRESSAN, J.. Effect of high-sucrose and high-fat diets ingested under free-living conditions in insulin resistance in normal-weight and overweight women. Nutr. Hosp. [online]. 2007, vol.22, n.1, pp.46-60. ISSN 1699-5198.

Objetive: The purpose of this study was to investigate the effect of high-sucrose diet (HSD) and high-fat diet (HFD) ingested under free-living conditions, on insulin homeostasis, as well verifies the association between insulin resistance and body composition as well. Research methods and procedures: 20 healthy women, 13 normal-weight (22.5 ± 2.1 years of age; BMI 22.2 ± 1.9 kg/m²) and 7 over-weight (21.8 ± 2.8 years of age; BMI 28.4 ± 3.2 kg/m²), included in 2 groups G1 and G2 respectively, they were randomized to intake HSD diets (59% carbohydrate including 23.0% of sucrose; 28.0% lipid; 13.0% protein; 20.2 g fiber) or HFD (42.0% carbohydrates including 1.3% of sucrose; 45.0% lipid; 13.0% protein; 22.2 g fiber) after initial assessment (BD). It was taken anthropometric measures, body composition and blood samples were obtained for fasting and post-prandial glucose and insulin determinations. Results: Glycemia, insulinemia and HOMA-IR did not differ between groups (p 0.05). Although on BD, HOMA-IR correlates positively with weight (r = 0.750), BMI (r = 0.929), waist circunference (r = 0.750) and percentage of total body fat (r = 0.857) for G2 group. The values of fasting HOMA-IR on BD were significantly greater than HFD for G1 group (p < 0.05). On HD the total carbohydrates and sucrose amount are greater than BD and HFD. Conclusion: The results confirm direct correlation between HOMA-IR, abdominal obesity and body fat. Therefore diet can modulate the insulinemic action.

Palavras-chave : HOMA-IR; Insulin; Glucose; Sucrose; Fat; Obesity.

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