Resumo

PUERTO-HERNANDEZ, B. et al. Effect on ocular blood flow of Combigan^® versus placebo in patients with ocular hypertension. Arch Soc Esp Oftalmol [online]. 2011, vol.86, n.2, pp.42-46. ISSN 0365-6691.

Purpose: This study was undertaken to compare the ocular haemodynamic effects of Combigan^® versus placebo in patients with ocular hypertension (OHT). Methods: Thirty patients with OHT were included in a controlled, randomised, double blind study in two parallel groups; 15 were randomised to receive Combigan^® and 15 to receive placebo for a period of 3 months. At baseline and at 3 months retrobulbar blood flowmeasurements of the ophthalmic artery (OA) and central retinal artery (CRA) were taken using colour Doppler imaging (CDI) ultrasound, concurrently with intraocular pressure (IOP). Results: Combigan^® significantly reduced IOP after 3 months of treatment (P = 0.001), whereas placebo showed no significant change in IOP. The baseline haemodynamic parameters were similar between treatment and placebo groups. Patients treated with Combigan^® showed a statistically significant decrease in CRA resistive index (P = 0.007). Conclusions: Patients treated for 3 months with Combigan^® showed a significant decrease of CRA resistive index that could be explained by the decrease in IOP.

Palavras-chave : Colour Doppler imagine; Ocular blood flow; Combigan^®; Central retinal artery; Ophthalmic artery; Rresistive index.

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