Meu SciELO
Serviços Personalizados
Journal
Artigo
Indicadores
Citado por SciELO
Acessos
Links relacionados
Citado por Google
Similares em SciELO
Similares em Google
Compartilhar
Revista Española de Enfermedades Digestivas
versão impressa ISSN 1130-0108
Resumo
SANZ-CASLA, M. T. et al. Prognostic significance of the p185 protein in colorectal cancer. Rev. esp. enferm. dig. [online]. 2004, vol.96, n.2, pp.102-109. ISSN 1130-0108.
The amplification and/or overexpression of the c-erbB-2/neu oncogene may play a role in tumor development and progression. The aim of this prospective study was to evaluate the prognostic value of p185 protein in colorectal cancer using immunohistochemical techniques. We analyzed 106 colorectal tumor tissue specimens from patients who had been operated on by the same surgeon and subjected to a median follow-up of 3 years. Thirty-three per cent of patients showed p185 overexpression related to an advanced stage of the disease. In patients with adenocarcinoma tumors of the colon without distant metastases, p185 detection was found to be of clinical prognostic relevance (p = 0.06).
Palavras-chave : c-erbB-2/neu oncogene; p185 protein; Colorectal carcinoma; Prognosis.