Meu SciELO
Serviços Personalizados
Journal
Artigo
Indicadores
Citado por SciELO
Acessos
Links relacionados
Citado por Google
Similares em SciELO
Similares em Google
Compartilhar
Anales del Sistema Sanitario de Navarra
versão impressa ISSN 1137-6627
Resumo
GOYENECHEA, E.; PARRA, M. D. e MARTINEZ HERNANDEZ, J. A.. Role of IL-6 and its -174G>C polymorphism in weight management and in the metabolic comorbidities associated with obesity. Anales Sis San Navarra [online]. 2005, vol.28, n.3, pp.357-366. ISSN 1137-6627.
Obesity and its comorbidities have been associated with a low grade proinflammatory state, in which the adipose tissue seems to be involved. In fact, this tissue produces different proinflammatory cytokines, such as IL-6 and others. High circulating concentrations of IL-6 have been related to high body mass index, to diabetes mellitus type 2, to lipid abnormalities and to high blood pressure. There are some studies, which reported a relationship between IL-6 and energy metabolism, so this cytokine and its -174GC gene polymorphism could be factors involved in the development of obesity. Different studies have associated the G allele of the IL-6 gene with obesity, with insulin resistance and with different cardiovascular risk factors. However, other published reports have associated the C allele of this gene to these metabolic disturbances and pathologies. This paper reviews recently published evidences about IL-6 and its physiopathological involvement in obesity and comorbidities, with emphasis on the role of the -174GC polymorphism in the aetiology of these disturbances, in which obesity is a major risk factor.
Palavras-chave : IL-6; Obesity; Diabetes; Polymorphism; High blood pressure.