Authors' conclusions:

in a prospective study, we validated the IgA anti tissue transglutaminase procedure and the IgA anti tissue transglutaminase-IgG anti deamidated gliadin procedure in identification of pediatric patients with or without celiac disease, without biopsy.

Reviewers' commentary:

although serological determinations are useful for the diagnosis of celiac disease and can allow diagnosis without duodenal biopsy, it seems reasonable to continue with the current recommendations, especially in groups of patients with low risk of disease.

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