Resumo

MARTINEZ PEREZ, J.M.  e  MARTINEZ RODRIGUEZ, J.M.. The cellular cytoskeleton in the mammary gland and its diagnostic application. Sanid. Mil. [online]. 2011, vol.67, n.2, pp.92-97. ISSN 1887-8571.

Objectives: To assess the importance of the changes that appear into the cytoskeleton (especially referred to some specific intermediate filaments called keratins) through different stages the mammary gland bears, focusing on the lactation. Their expression will be different in pathological conditions and this will be useful for contrasting other procedures. Design: 40 mice distributed into five groups according to the stage of study. The experimental project is the same for everyone. Material and methods: Immunohistochemical analysis from samples obtained from mammary glands in order to show changes into cytokeratin expression and comparison with other researches in different animal models. Results: The expression of every cytokeratin is different according to the cell lineage and the lactation period. Specific antibodies can reveal it. Conclusions: The cytokeratinic pattern changes in a physiological sense and also in malignant processes. Immunohistochemical detection of cytokeratins may be useful as complementary diagnosis.

Palavras-chave : Cytoskeleton; intermediate filaments; cytokeratin; mammary gland; cancer.

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