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Revista Andaluza de Medicina del Deporte
versão On-line ISSN 2172-5063versão impressa ISSN 1888-7546
Resumo
SILVA, C.M.S. et al. Effects of aerobic and resistance training of long duration on pro- and anti-inflammatory cytokines in rats. Rev Andal Med Deporte [online]. 2017, vol.10, n.4, pp.170-175. ISSN 2172-5063. https://dx.doi.org/10.1016/j.ramd.2016.02.005.
Objective:
To determine possible changes in serum concentrations of pro- and anti-inflammatory cytokines of eutrophic rats subjected to aerobic or resistance physical training.
Methods:
This study examined serum concentrations of TNF-α, IFN-γ, IL-6, IL-10 and IL-1-β in rats that performed aerobic or resistance training for 16 weeks. Thirty-five Wistar rats (male adult) were divided into three groups: Control Group (CG), Aerobic Group (AG) and Resistance Group (RG). Rats were sacrificed 48 h after the final training session. Serum concentrations of cytokines were analysed by ELISA.
Results:
TNF-α levels were higher in the RG, followed by the AG and CG groups (p < 0.001). IFN-γ and IL-10 levels were not significantly different between groups (p = 0.097 and p = 0.17, respectively). The levels of IL6 and IL1-β were higher in AG compared to RG and CG (p = 0.0004 and p = 0.003, respectively). In general, our results indicate a higher pro-inflammatory profile in AG and probably RG animals.
Conclusion:
Further studies are required in order to better clarify the effects of aerobic and resistance exercise training on pro- and anti-inflammatory cytokines. Additionally, future studies should address the metabolic and molecular pathways involved in these responses.
Palavras-chave : Aerobic training; Resistance training; Cytokines; Inflammation.