Meu SciELO
Serviços customizadosServiços Personalizados
Journal
Artigo
Inglês (pdf)
Artigo em XML
Referências do artigo
Tradução automática
Enviar este artigo por emailIndicadores
Citado por SciELO 
Acessos
Links relacionados
Citado por Google 
Similares em
SciELO 
Similares em Google
Compartilhar
Permalink
Revista de Osteoporosis y Metabolismo Mineral
versão On-line ISSN 2173-2345versão impressa ISSN 1889-836X
Resumo
SALMON-GONZALEZ, Z et al. Influence of high-concentration hyperbaric oxygen therapy on bone metabolism. Rev Osteoporos Metab Miner [online]. 2020, vol.12, n.1, pp.28-31. Epub 15-Jun-2020. ISSN 2173-2345. https://dx.doi.org/10.4321/s1889-836x2020000100005.
Objectives:
To learn how high concentration in hyperbaric oxygen therapy (HBO) acts on the expression of genes related to bone metabolism in osteoblast cell lines and human trabecular bone.
Material and methods:
The differential expression of several genes related to bone metabolism (SOST, RUNX2, MMP14, OPG, HIF-1α and SIRT1) in two human osteoblastic cell lines (Saos and Super-Saos) and in human trabecular bone fragments subjected to one, three or five HBO sessions (90 minutes, 100% oxygen; 2.3 atmospheres). In each experiment, a control that did not receive HBO was used.
Results:
We did not find significant differences after HBO in the expression of the genes studied, neither in the cells nor in trabecular bone. Only in the Super-Saos cell line the expression of OPG after 5 sessions of HBO decreased 6 times with respect to that of the control group (2-ΔCt Ct of 72; p=0.01).
Conclusions:
High concentration oxygen in the hyperbaric chamber (HC) does not seem to influence the expression of
genes related to bone metabolism.
Palavras-chave : Oxygen; hyperbaric chamber; bone; genes.
