Background:

At the beginning of 2021, more than 110 million people had been infected with SARS-CoV-2. The urgent need for safe and effective interventions to mitigate the global spread of SARS-CoV-2 has prompted international efforts to develop antivirals and vaccines. Pharmacovigilance for adverse events after vaccination is relevant; the undesirable sign or symptom that manifests in an individual who has received some type of vaccination is considered an adverse event.

Purpose:

To analyse the level of knowledge and motivation for getting vaccinated against SARS-CoV-2 in a hospital staff to the administered COVID-19 mRNA vaccine, to describe the Adverse Events Following Immunization and to compare it with the last notifications published by our national agency of drugs and medical devices.

Methods:

This is a descriptive, observational, and prospective study. The sample was composed of 66 hospital workers who were vaccinated with COVID-19 mRNA vaccine.

Results:

More than 80% of the sample showed adverse events following immunisation. The most frequently AEFI reported was injection site reactions. The knowledge about the AEFI determines motivation for getting vaccinated. Motivation for getting vaccinated is related with have taken medication: staff who is more motivated to get vaccinated needed less medication to alleviate symptoms and is more likely of being willing to put new doses if necessary. About 26% of the sample revealed anxious, fearful, or worried for being vaccinated.

Conclusions:

About 75% of the sample answered that they were motivated for getting vaccinated. The study cases present injection site reactions, fatigue, weakness, and arthralgia; the shaking chills were more frequent than literature and pyrexia was less frequent than literature. All AEFI were more frequent after dose 2. The knowledge about the AEFI determines motivation for getting vaccinated.

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