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Iberoamerican Journal of Medicine
versão On-line ISSN 2695-5075versão impressa ISSN 2695-5075
Resumo
KUCUK, Uğur e ARSLAN, Kadir. Fibrosis-4 index: a new marker to predict non-dipper blood pressure pattern in patients with newly diagnosed hypertension. Iberoam J Med [online]. 2022, vol.4, n.1, pp.52-59. Epub 22-Jan-2024. ISSN 2695-5075. https://dx.doi.org/10.53986/ibjm.2022.0011.
Introduction:
Epicardial fat tissue (EFT) is a significant risk factor for cardiovascular diseases. This study aimed to investigate whether there is a relationship between the fibrosis-4 index (FIB-4 index) and EFT in newly-diagnosed hypertensive patients and explore the usability of the FIB-4 index in predicting non-dipper blood pressure (BP) pattern.
Materials and methods:
Our case–control study consisted of 210 patients in 3 groups according to BP values, namely normotensive, dipper, and non-dipper groups. Transthoracic echocardiography and 24-h ambulatory BP monitoring were performed in all patients.
Results:
The median FIB-4 index was higher in the non-dipper group [1.56 (1.10-2)] than in the dipper [1 (0.71-1.32)] and normotensive groups [0.96 (0.69-1.32)] (p < 0.001, for both). A positive correlation was observed between EFT and the FIB-4 index (r=0.389, p<0.001). In multivariate logistic regression analysis, EFT (odds ratio (OR): 0.506, 95% confidence interval (CI): 1.288-2.135; p<0.001) and FIB-4 index (OR: 1.099, 95% CI: 1.621–5.556; p<0.001) were found to be independent predictors of non-dipper BP. In the receiver operating characteristic curve analysis, the FIB-4 index had 68% sensitivity and 72% specificity at a value >1.25 (area under the curve: 0.751, 95%CI: 0.679-0.823, p<0.001).
Conclusions:
In newly-diagnosed hypertensive people, the FIB-4 index is related to non-dipper BP patterns. FIB-4 index appears to be a helpful tool in assessing risk associated with cardiovascular disease.
Palavras-chave : Hypertension; Non-dipper; Fibrosis-4 index; Epicardial adipose tissue.