Resumen

BRANDA SICA, A. et al. Evaluation of panel SNP in metabolic pathways candidate genes for meat in Hereford. Arch. zootec. [online]. 2014, vol.63, n.241, pp.73-84. ISSN 1885-4494.  https://dx.doi.org/10.4321/S0004-05922014000100008.

The phenotype-genotype associations of a panel of SNP markers selected from candidate genes related to the growth hormone GH/ IGFIendocrine axis and the fatty acid synthesis and desaturation SCD/SREBP1 pathways, were examined. Phenotypes of interest were carcass composition, meat quality and fatty acid profiles of intramuscular fat in Hereford steers under different feeding treatments during the growth and finishing stages. Variables were adjusted for the effect of eight nutritional treatments and residual values were used in the association analysis with the SNP markers. A total of 11 696 genotypes of 237 steers were determined using a panel of 58 tag-SNP in the GHR, IGF1, IGFBP6, PMCH, SOCS2, STAT6, SCD1, SCD5, SREBP1, SCAP, INSIG1, INSIG2, MBTPS1, MBTPS2 and SRPR genes. A total of 11 polymorphic SNP were significantly associated with traits of interest: GHR_ rs41639262 on EGSu and MARBL; IGF1_ rs136251088 on PCC, PCE and PISTOLA; PMCH_ rs135033882 on OME-GA36; SOCS2_ ss252841026 on Terneza2d; STAT6_ rs109171041 on Terneza2d; STAT6_rs110097583 on Terneza2d; INSIG1_ rs109314460 on Terneza21d; INSIG1_ ss252452220 on OME-GA36; SCD5_ ss252452202 on PUFA and Terneza2d; SCD5_ rs43687655 on EGSu and OMEGA36; SRPR_ rs42178091 on GRASAINTR, SFA, MUFA, PCC, PCE and PISTOLA. Additional studies could validate the marker-trait association effects that would make it possible to use these genetic markers to improve carcass and meat quality of animals under different feeding regimes.

Palabras clave : Beef cattle; Carcass composition; Meat quality; Fatty acid profile.

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