Abstract

GONZALO RODRIGUEZ, Victoria et al. The use of NMP22 Bladder-Chek for the diagnosis and folow-up of bladder cancer. Arch. Esp. Urol. [online]. 2008, vol.61, n.3, pp.377-384. ISSN 0004-0614.

Objectives: The goal of this work is to evaluate the usefulness of NMP22 BladderChek in the diagnosis and follow-up of bladder cancer, comparing it with cystoscopy and urine cytology. Methods: Group 1: 109 asymptomatic patients on follow up for bladder cancer underwent cystoscopy, cytology and NMP22 BladderChek. Group 2: 15 patients with history of hematuria underwent cystoscopy and NMP22 BladderChek. Results: Group 1: 9 patients had tumor relapse. Sensitivity was 25% for NMP22 test, 50% for citology and 100% for cystoscopy. Specificity was 91.1%, 94.1% and 95% respectively. Group 2: 12 patients had bladder cancer. The sensitivity was of 83.3% for NMP22 BladderChek and 100% for cystoscopy. The specificity was of 100% for NMP22 BladderChek and 66.7% for cystoscopy. Conclusions: The low sensitivity of NMP22 Bladder-Chek invalidates it as alternative method to cystoscopy in the follow-up of bladder cancer. But it can be recommended for screening in patients without history of bladder cancer but with an increased risk (smokers, patients with dysuria and hematuria).

Keywords : Bladder Cancer; NMP22 BladderChek; Cystoscopy; Citology.

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