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Archivos Españoles de Urología (Ed. impresa)
versión impresa ISSN 0004-0614
LOPEZ FONTANA, Constanza M. et al. Influence of leptin and adiponectin on prostate cancer. Arch. Esp. Urol. [online]. 2009, vol.62, n.2, pp.103-108. ISSN 0004-0614.
Objectives: Many studies have investigated the association between obesity, adipose tissue-derived factors (leptin and adiponectin) and prostate cancer (CaP) but the results are still inconsistent. Methods: The aim of this study was to carry out a comprehensive review of the existing evidence about the role of leptin and adiponectin in prostate carcinogenesis and to provide an overview of it. Results: Recent evidence suggests that leptin may play a rol in prostate cancer progression, while adiponectin may act as an "anti- prostatic cancer" adipokine. Conclusions: Obesity may promote the progression of established prostate cancer and and adipokines may provide a molecular mechanism whereby obesity exerts its effects on prostate tumour biology.
Palabras clave : Adiponectin; Leptin; Obesity; Prostate cancer.