Abstract

SERVER PASTOR, G. et al. Oral Tegafur and intravesical mitomycin versus intravesical mutomycin alone in the prophylaxis of Ta bladder carcinoma recurrence. Actas Urol Esp [online]. 2003, vol.27, n.6, pp.438-441. ISSN 0210-4806.

OBJECTIVE: The aim of this study is to know if the use of oral Tegafur associated to intravesical mitomycin is effective in the prevention of the relapses of Ta bladder tumors. METHOD: This is a prospective study in which we compare the recurrence rate and the diseasefree interval of 2 groups of 40 patients each one, the first of them treated after the TUR with oral Tegafur and intravesical mitomycin, and the second with intravesical mitomycin alone. Tolerance of Tegafur was also studied. RESULTS: The group of the Tegafur presented a descent of the relapse rate and a continuation of the time free of illness; but it was not statistically significant. The tolerance to the fármaco was good, not appearing important adverse effects. CONCLUSIONS: Tegafur seems an useful drug in the prevention of the recurrence of superficial bladder tumors, although it will be necessary bigger studies to reach statistically valid conclusions.

Keywords : Tegafur; Bladder cancer; Chemotherapy.

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