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Actas Urológicas Españolas

versión impresa ISSN 0210-4806

Resumen

OJEA CALVO, A. et al. The usefulness of ki67 expression in the biopsy specimens, to predict the biochemical progresion of the prostate cancer after radical prostatectomy. Actas Urol Esp [online]. 2004, vol.28, n.9, pp.650-660. ISSN 0210-4806.

OBJETIVE: To evaluate the usefulness of Ki67 expression in the biopsy specimens, to predict the biochemical progression of the prostate cancer after radical prostatectomy. MATERIAL AND METHODS: We analyse the Ki67 expression in the biopsy specimens of 103 patients treated with radical prostatectomy. The mean follow up is 3.4 years (1.3-8.8 years). We correlate the biochemical progression with traditional prognostic factors as the PSA (>10/≤10), Gleason (≥7/<7), pT ification (pT3/pT0-2) and immunohistochemical factor Ki67 (>3%/≤3%). RESULTS: Of all 103 patients, in 71 (69%) biochemical progression was not detected and in 32 (31%) biochemical progression was detected. The mean of preoperative PSA is 10.07 ng/ml in the patients without progression and 20.90 ng/ml in the patients with biochemical progression (p=0.0001). The mean of Gleason score in 6.03 in the patients without progression and 6.75 in the patients with biochemical progression (p=0.0001). The percentage of Ki67 expression is 3.95% in the patients without progression and 5.05% in the patients with biochemical progression (p=0.030). The tumors pT0-2 progressed 12/67 (17.9%) and the tumors pT3 progressed 20/36 (55.6%) (p=0.0001). Multivariant regression analysis indicate that it does not exist a statistically significant relation between Ki67 (>3%/≤3%) expression in the biopsy specimens and the biochemical progression of the prostate cancer after radical prostatectomy (p=0.204). CONCLUSIONS: The immunohistochemical factor Ki67 (>3%/≤3%) in the biopsy specimens, is less effective than the ic factors, PSA (>10/≤10), Gleason (≥7/<7) and pT ification (pT3/pT0-2), to predict the biochemical progression of the prostate cancer after radical prostatectomy.

Palabras clave : Prostate cancer; Radical prostatectomy; Biochemical progression; Prognostic factors; Ki67.

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