Actas Urológicas Españolas
versión impresa ISSN 0210-4806
GOMEZ PEREZ, L. et al. Role of chronic prostatic infiltrate from specimens of prostate biopsy in total and free PSA determination. Actas Urol Esp [online]. 2005, vol.29, n.2, pp.170-173. ISSN 0210-4806.
Purpose: To analyze the influence in total serum PSA (PSAt) and free PSA (PSAl) of chronic inflammatory patterns from prostate biopsy specimens of non-symptomatic patients. Patients and methods: 518 non-symptomatic patients underwent ultrasonography and prostatic biopsy for PSAt> 4 ng/mL and/or DRE suspicious of malignancy. Those with a negative biopsy were divided into two subgroups: patients with benign prostatic lesions (LBP) and patients with chronic inflammatory signs (SIC). Results: 456 patients (88.03%) were biopsied for elevated PSAt or/and DRE suspicious of malignancy in 62 patients (11.97%). Mean volume in patients with LBP was 54cc, while 51cc was the mean volume in patients with histological pattern of chronic inflammatory infiltrate. Mean PSAt in patients with LBP was 9.43 (IC 95% ± 7.8) and 8.8 (IC 95% ± 5.73) in SIC's group patients. Conclusions: The presence of SIC has no significant influence in the eventual value of PSAl y PSAt in a selected population. As a result of that finding data from serum PSA can be reliably evaluated even in the presence of SIC in biopsy specimens.
Palabras clave : Chronic inflammation; PSA; Prostate biopsy.