Abstract

RIVERA, G. Pedro; GONZALEZ, I. Rodrigo; GONZALEZ, I. Felipe  and  STORME, C. Oscar. Use of paroxenetine on-demand in premature ejaculation. Actas Urol Esp [online]. 2005, vol.29, n.4, pp.387-391. ISSN 0210-4806.

Introduction: It has been described varied definitions of premature ejaculation (PE), which has determined different prevalences and rates of success for the different therapies with selective serotonin re-uptake inhibitors. Our goal was evaluate the effectiveness of paroxetine like treatment of premature ejaculation administered ondemand (4-6 hours previous to intercourse) compared to the scheme of daily dose. Patients and method: A prospective study type crossover was designed with 14 patients. Grupo A: 7 patient received paroxetine 20 mg /d by three weeks followed by paroxetine 20 mg 4-6 hours before the intercourse by three weeks. Group B: the other 7 patients received the same scheme but replacing by placebo. Later to three weeks of therapy suspension, crossover was made. Results: The intravaginal ejaculatory latency time (IELT) pre-treatment was 0,4 minutes. In the group A the IELT average was of 4,3 minutes in the treatment with daily paroxetine; 5,8 minutes when they received paroxetine on-demanad; 0.9 with daily placebo and 0,6 with placebo on-demand (p < 0.001). For group B the IELT during the daily placebo was 0,8 minutes and with placebo on-demand it was of 1,1 . When they received daily paroxetine the IELT was 3,3 minutes and during the phase of paroxetine on-demand it was increased to 6,1 (p<0.001). Conclusions: The treatment of premature ejaculation with paroxetine in daily dose and scheme on-demand appears similar like effective options.

Keywords : Premature ejaculation; Paroxetine.

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