Abstract

GELPI-MENDEZ, J.A. et al. Reference values of prostate specific antigen (PSA) in 63926 workers without prostatic symptoms who participated in prostate screening cancer developed by the Ibermutuamur Prevention Society in 2006. Actas Urol Esp [online]. 2010, vol.34, n.8, pp.669-676. ISSN 0210-4806.

Objective To determine the values of PSA in Spanish workers without history of prostate problems and compare them with other geographical latitudes. Methods: Observational, retrospective, multicenter and population-based study, conducted between January 1 and December 31, 2006. A total of 65303 workers participated in the Programme of prostate cancer screening conducted by the Ibermutuamur Prevention Society in different Spanish regions. Of these, were selected for this report, 63926: 149 were excluded by personal history of prostate problems and 1328 for being over 64 years. PSA determinations were performed using the Abbott test. Were specified PSA values for each age and for the following age ranges: younger than 40 years, 40-49 years, 50-59 years and 60-64 years. Also calculated the mean PSA values by Autonomous Communities. The data were expressed as mean (±SD), confidence intervals 95%, standard error of the mean (SEM) and in the percentiles 5, 25, 50, 75 and 95. The results obtained were compared with those in other areas of the world. All data were analysed using the statistical software GraphPad Quick Calcs. Results: Mean PSA value: for all cases was 1.06ng/ml (95% CI: ±1,18) and age groups: under 40 years, 0.67ng/ml (95% CI: ±0.49), 40-49 years, 0, 77ng/ml (95% CI: ±0.66), 50-59 years, 1.11ng/ml (95% CI: ±1.22) and 60-64 years, 1.57ng/ml (95% CI: ±1.72). Depending on the age ranged between 0.67ng/ml under age 40 and 1.70 in the 64 years. According to region, the lowest value was recorded in the País Vasco with 0.98ng/ml (95% CI: 1.02) and higher in Asturias with 1.28ng/ml (95% CI: 1.32). Percentile value PSA: the upper normal limit (95th percentile) was 1.40ng/ml in those younger than 40 years, 1.70ng/ml in 40-49 years, 3.30ng/ml in 50-59 years and 5.18ng/ml in the group 60-64 years. Conclusions: PSA values collected in this study may serve as a reference for the Spanish working population, using the range described for decades, or even better, those relating to each age.

Keywords : Reference values of PSA; Prostate cancer screening; Health surveillance of workers.

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