SciELO - Scientific Electronic Library Online

vol.34 número8Utilidad del Doppler transcraneal en la resucitación de la parada cardíacaParada cardíaca por hipotermia accidental y resucitación cardiopulmonar prolongada índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados




Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google


Medicina Intensiva

versión impresa ISSN 0210-5691


SIRGO, G. et al. Dendritic cells in sepsis: An approach to post-infectious immunosuppression. Med. Intensiva [online]. 2010, vol.34, n.8, pp.559-566. ISSN 0210-5691.

Dendritic cells (DCs) play a decisive role in the immune system, especially in the initial events that determine coordination between the innate and adaptive response. Moreover, they are antigen-presenting cells which, through contact with T cells, determine the type of immune responses towards inflammatory or anti-inflammatory. Currently, the hypothesis that attributes importance to the development of a post-infectious immunosuppression in the prognosis of the septic patient is growing stronger. It has been possible to verify the role played by these cells in this type of immunosuppression by the significant decrease in the number of DCs and by the dysfunctions in the functional capacity that include, on the one hand, the abnormal cytokine production and, on the other hand, the alterations in communication between the DCs and T cells that constitute an essential immunological fact. Further research into the knowledge regarding the DCs, in the context of severe infection, may help to consolidate some encouraging data that indicate these cells as: 1) an effective tool for monitoring the acute infection, 2) a discriminatory variable that may help determine the risk of nosocomial infection and 3) in a longer term, a treatment target that would restore the immunological abnormalities that occur in sepsis.

Palabras clave : Sepsis; Dendritic cells; Immunosuppression.

        · resumen en Español     · texto en Español     · Español ( pdf )


Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons