SciELO - Scientific Electronic Library Online

 
vol.30 número4Hipertensión arterial en su encrucijada: a la búsqueda de una definición operativa índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Articulo

Indicadores

Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google

Compartir


Nefrología (Madrid)

versión impresa ISSN 0211-6995

Resumen

FLAQUER, M.; ROMAGNANI, P.  y  CRUZADO, J.M.. Growth factors and renal regeneration. Nefrología (Madr.) [online]. 2010, vol.30, n.4, pp.385-393. ISSN 0211-6995.

Cell replenishment is critical for adult tissue repair after damage. In some organs this process is facilitated by stem cells. In contrast to the liver, the kidney has limited capacity for regeneration. Nevertheless, there are several recent studies suggesting the presence of stem cells in the adult kidney. Stem cell renal niches have been identified in the renal papillae in animals as well as in the urinary pole of the Bowman capsule in humans (CD24+CD133+ stem cells). Although these cells may contribute to organ regeneration, how these cells exert this effect and their role after kidney damage is not known. Nevertheless, renal stem cells may be therapeutic targets for treatment of renal diseases. On the other hand, bone marrow derived stem cells may also contribute in renal repair, particularly mesenchymal stem cells. However, the mechanism for producing such effect has not been elucidated. Some studies suggest there is cell fusion between bone marrow and resident tubular cells; others suggest bone marrow cells are able to differentiate in resident cells, while some authors propose bone marrow cells facilitate organ regeneration by a paracrine action; that is by secreting growth factors as hepatocyte growth factor 1. All these secreted molecules would provide a regenerative milieu able to constrain renal damage and to amplify stem cells migration to the damaged organ.

Palabras clave : Renal regeneration; stem cells; hepatocyte growth factor; bone marrow.

        · resumen en Español     · texto en Español     · Español ( pdf )

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons