Abstract

SANS ATXER, L. et al. Relationship between kidney size and blood pressure profile in patients with autosomal dominant polycystic kidney disease without renal failure. Nefrología (Madr.) [online]. 2010, vol.30, n.5, pp.567-572. ISSN 1989-2284.

Background: Enlargement of renal size plays an important role in the development of hypertension in patients with autosomal dominant polycystic kidney disease (ADPKD) and normal renal function. Methods: A 24h blood pressure monitoring (ABPM) and a renal ecography have been performed in 37 patients with ADPKD and estimated glomerular filtration rate >60 ml/min/1,73m² to study the relationship between renal size and an altered blood pressure profile in prehypertension stages. Results: 13 patients had normal blood pressure, 11 were diagnosed of masked hypertension, 4 had white coat hypertension and 9 had hypertension. We have found in the normotensive group with a dipper blood pressure profile a positive and statistically significant relationship between renal size and diastolic blood pressure variability. Conclusions: ABPM helps to make an early diagnosis of hypertension and to identify those patients with masked hypertension. This study suggests a relationship between renal size and a blood pressure profile linked to a major cardiovasular risk in normotensive patients with ADPKD.

Keywords : Autosomic dominant polycystic kidney disease; Renal size; Ambulatory monitoring of blood pressure; Blood pressure profile; Blood pressure variability.

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