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Nefrología (Madrid)

On-line version ISSN 1989-2284Print version ISSN 0211-6995


GORRIZ, José L.  and  SOCIEDAD ESPANOLA DE ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA (SEIMC). Panel de Expertos del Grupo de Estudio de Sida (GESIDA) et al. Executive summary of the consensus document on the management of renal disease in HIV-infected patients. Nefrología (Madr.) [online]. 2014, vol.34, n.6, pp.768-788. ISSN 1989-2284.

The aim of this article is to update the 2010 recommendations on the evaluation and management of renal disease in HIV-infected patients. Renal function should be monitored in all HIV-infected patients. The basic renal work-up should include measurements of serum creatinine, estimated glomerular filtration rate by CKD-EPI, urine protein-to-creatinine ratio, and urinary sediment. Tubular function tests should include determination of serum phosphate levels and urine dipstick for glucosuria. In the absence of abnormal values, renal screening should be performed annually. In patients treated with tenofovir or with risk factors for chronic kidney disease (CKD), more frequent renal screening is recommended. In order to prevent disease progression, potentially nephrotoxic antiretroviral drugs are not recommended in patients with CKD or risk factors for CKD. The document provides indications for renal biopsy and advises on the optimal time for referral of a patient to the nephrologist. The indications for and evaluation and management of dialysis and renal transplantation are also addressed.

Keywords : AIDS; HIV; Chronic kidney disease; Renal failure; Tenofovir; Renal toxicity; Antiretroviral therapy; Renal transplant.

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