Abstract

RODRIGUEZ-OSORIO, Laura et al. Using sevelamer in chronic kidney disease: beyond phosphorus control. Nefrología (Madr.) [online]. 2015, vol.35, n.2, pp.207-217. ISSN 1989-2284.

Sevelamer is a calcium-free phosphate binder used in advanced chronic kidney disease (CKD) and in dialysis to control hyperphosphatemia. Several experimental and observational studies and clinical trials have shown that sevelamer has pleiotropic effects that go beyond controlling hyperphosphatemia; these pleiotropic effects include acting on inflammation, oxidative stress, lipid profile and atherogenesis, vascular calcification, endothelial dysfunction and decreasing various uremic toxins. All of these represent the biological basis for the global effect of sevelamer on cardiovascular morbidity and mortality in patients with CKD. In this review, we emphasis these pleiotropic actions of sevelamer and their impact on cardiovascular health, with the experience published after more than 10 years of clinical experience.

Keywords : Sevelamer; Phosphate; Pleiotropic effects; Inflammation; Gut.

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