SciELO - Scientific Electronic Library Online

 
vol.36 número1El impacto de los nefrólogos intervencionistas en el crecimiento de un programa de diálisis peritoneal: la experiencia de un centro único a largo plazo índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

Links relacionados

  • Em processo de indexaçãoCitado por Google
  • Não possue artigos similaresSimilares em SciELO
  • Em processo de indexaçãoSimilares em Google

Compartilhar


Nefrología (Madrid)

versão On-line ISSN 1989-2284versão impressa ISSN 0211-6995

Resumo

EGIDO, Jesús et al. The pleiotropic effects of paricalcitol: beyond bone-mineral metabolism. Nefrología (Madr.) [online]. 2016, vol.36, n.1, pp.10-18. ISSN 1989-2284.  https://dx.doi.org/10.1016/j.nefro.2015.11.003.

Secondary hyperparathyroidism (SHPT) is a common complication in patients with chronic kidney disease (CKD) that is characterised by elevated parathyroid hormone (PTH) levels and a series of bone-mineral metabolism anomalies. In patients with SHPT, treatment with paricalcitol, a selective vitamin D receptor activator, has been shown to reduce PTH levels with minimal serum calcium and phosphorus variations. The classic effect of paricalcitol is that of a mediator in mineral and bone homeostasis. However, recent studies have suggested that the benefits of treatment with paricalcitol go beyond PTH reduction and, for instance, it has a positive effect on cardiovascular disease and survival. The objective of this study is to review the most significant studies on the so-called pleiotropic effects of paricalcitol treatment in patients with CKD.

Palavras-chave : Vitamin D; Secondary hyperparathyroidism; Parathyroid hormone; Vascular calcification; Atherosclerosis; Proteinuria; Dialysis; Transplant.

        · resumo em Espanhol     · texto em Espanhol     · Espanhol ( pdf )

 

Creative Commons License Todo o conteúdo deste periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons