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Nutrición Hospitalaria

On-line version ISSN 1699-5198Print version ISSN 0212-1611


LUIS, D. A. de; IZAOLA, O.; FUENTE, B. de la  and  ARAUJO, K.. Blood glucose and insulin responses to two hypocaloric enteral formulas in patients with diabetes mellitus type 2. Nutr. Hosp. [online]. 2013, vol.28, n.3, pp.600-606. ISSN 1699-5198.

Objectives: The aim of this study is to compare the glycaemic and insulinemic response of type 2 diabetic patients after oral administration of 250 ml of two enteral formulas: a specific formula (Novasource® Diabet Smartflex®) against a standard isocaloric formula. Methods: The design was a cross-over study, with the diabetic patients (n = 15) receiving one of the two formulas in random order. Glycaemia and insulinemia curves were performed at 0, 10, 20, 30,60, 90,120,150 and 180 minutes. The variables studied were the area under the curve (AUC0-t), maximum concentration (Cmax), the time to reach maximum concentration (Tmax) and the concentrations of biochemical parameters in each study period. Results: We studied 11 males (73.3%) and 4 females (26.7%), the mean age was 56.9 ± 10.9 years. Patients receiving Novasource® Diabet showed a lower mean AUC0-t of glucose, mean difference -4,753.26 mg/min/dl (95% CI: -7,256.7 to -2,249.82), also showed a mean insulinemia significantly lower AUC0-t, mean difference: 930.27 uU/min/ml (95% CI -1,696.34 to -164.2). The Cmax showed a significantly lower mean blood glucose levels with the specific formula, mean difference -26.89 mg/dl (95% CI -42.11 to -11.67) and insulin, mean difference: -5.39 uU/ml (95% CI: -10.37 to -1.43). The analysis shows that the mean Tmax of glucose with the specific formula are significantly lower, mean difference -19.82 min (95% CI: -32.11 to -7.33), however there was no difference in Tmax of insulin. Finally the analysis of glucose concentrations in the total study shows that the group with the specific formula has a lower mean glucose 25.77 mg / dl (95% CI 18.29 to 33.25), the same fact was detected with insulinemia 4.39 mU/ml (95% CI: 0.927 to 7.87). Conclusions: Diabetic patients treated diabet Novasource® had significantly lower mean AUC0-t, Cmax and Tmax in blood glucose curves, also had lower mean AUC0-t and Cmax in insulin curves.

Keywords : Glucose; Insulin levels; Enteral specific formulas.

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