SciELO - Scientific Electronic Library Online

 
vol.28 issue4Adherence to nutritional therapy in obese adolescents: a reviewEnergy availability, menstrual dysfunction and bone health in sports: an overwiew of the female athlete triad author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google

Share


Nutrición Hospitalaria

On-line version ISSN 1699-5198Print version ISSN 0212-1611

Abstract

SOTOS-PRIETO, Mercedes  and  PENALVO, José Luis. Genetic variation of apolipoproteins, diet and other environmental interactions: an updated review. Nutr. Hosp. [online]. 2013, vol.28, n.4, pp.999-1009. ISSN 1699-5198.  http://dx.doi.org/10.3305/nh.2013.28.4.6475.

This paper summarizes the recent findings from studies investigating the potential environmental modulation of the genetic variation of apolipoprotein genes on metabolic traits. We reviewed nutrigenetic studies evaluating variations on apolipoproteins-related genes and its associated response to nutrients (mostly dietary fatty acids) or any other dietary or environmental component. Most revised research studied single nucleotide polymorphism (SNP) and specific nutrients through small intervention studies, and only few interactions have been replicated in large and independent populations (as in the case of -265T > C SNP in APOA2 gene). Although current knowledge shows that variations on apolipoprotein genes may contribute to the different response on metabolic traits due to dietary interventions, evidence is still scarce and results are inconsistent. Success in this area will require going beyond the limitations of current experimental designs and explore the hypotheses within large populations. Some of these limitations are being covered by the rapidly advance in high-throughput technologies and large scale-genome wide association studies.

Keywords : Apolipoprotein; Gene-diet interaction; Environment; Nutrigenetics; Dietary interventions.

        · abstract in Spanish     · text in English     · English ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License