SciELO - Scientific Electronic Library Online

 
vol.28 número6Efectos sobre el perfil lipídico en humanos de un extracto de algarroba (ceratonia siliqua L.) rico en polifenoles, incluido en un lácteo como alimento funcional: estudio pilotoÉxito de la gestión de la ascitis con nutrición parenteral total y octreótida en niños índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google

Compartir


Nutrición Hospitalaria

versión On-line ISSN 1699-5198versión impresa ISSN 0212-1611

Resumen

GONZALEZ DE DIOS, Javier  y  GONZALEZ MUNOZ, María. Probiotics and necrotizing enterocolitis in preterm infants: to NEC or not to NEC?, this is the question. Nutr. Hosp. [online]. 2013, vol.28, n.6, pp.2115-2123. ISSN 1699-5198.  http://dx.doi.org/10.3305/nh.2013.28.6.6901.

Introduction: Necrotizing enterocolitis (NEC) is the most commonly acquired neonatal intraabdominal emergency and causes significant morbidity and mortality. A proposed strategy for the prevention of NEC in preterm infants is the administration of oral probiotics. The objective of the study is to analyze the efficacy and safety of oral probiotics in preterm infants to try to answer the following question: oral probiotics in Neonatology, yes or no? Methodology: A scheme of work based on the five standard steps of medicine based on scientific evidence (EBM) was used: 1) question, 2) search, 3) valuation, 4) applicability and 5) adequacy. Electronic searches were performed on international (Tripdatabase, Cochrane Collaboration, National Guideline Clearinghouse, Guia-Salud, INHATA, Medline, SciELO) and national (índice Médico Español, índice Bibliográfico Español en Ciencias de la Salud y MEDES) database. Results: we selected 8 systematic reviews (SR) that answered our clinical question, published between 2007 and 2012, and which included the best available information (randomised clinical trials). Risk of death was significantly reduced in probiotic groups in all SR, with relative risk (RR) 0,40 to 0,56. Risk of NEC was significantly reduced in probiotic groups in all SR, with RR 0,32 to 0,36. Risk of sepsis did not differ significantly between groups. Conclusions: The findings of the 8 SR show potential prevention of oral probiotics in mortality and morbidity secondary to NEC. However, they must be interpreted with caution because the beneficial effects of probiotics seem to be strain specific, thus, pooling data from different strains may result in misleading conclusions. We found two groups of investigation in this field ("yes, of course" and "no, be careful") and there is encouraging data which justifies further and definitive clinical trial regarding the efficacy and safety of specific probiotics in circumstances of high local incidence of severe NEC.

Palabras clave : Low birth weight; Necrotizing enterocolitis; Preterm infant; Probiotic agents; Effectiveness; Security; Systematic reviews; Evidence-based medicine.

        · resumen en Español     · texto en Español     · Español ( pdf )

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons