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Nutrición Hospitalaria

On-line version ISSN 1699-5198Print version ISSN 0212-1611


LINARES GUERRA, Elisa Maritza et al. Nutritional status of the persons living with HIV/Aids: its relationship woth T CD4+ cells counts. Nutr. Hosp. [online]. 2013, vol.28, n.6, pp.2201-2211. ISSN 1699-5198.

Rationale: Malnutrition might be present in people living with HIV/aids (PHIV/aids), and be associated with derangement of the immune system. Objective: To assess the association between the nutritional status of the PHIV/aids and the counts of T CD4+ cells. Study design: Observational, analytical and cross-sectional. Methods: The nutritional status of 217 PHIV/aids in the Pinar del Río province, Cuba (Men: 72.4%; Age at the moment of HIV/aids diagnosis: < 30 years: 62.2%; CD4+ Counts < 350 32.3%; Anti-retroviral therapy: 33.2%) was indistinctively established by means of the Body Mass Index (BMI), the Global Subjective Assessment (SGA) and the Chang's algorithm. The association between the nutritional status and the CD4+ counts was estimated from the corresponding odds-ratios (OR), indistinctively calculated from the cross-products ratios of a 2 x 2 contingency table; or the coefficients of the logistic regression model. Results: Malnutrition frequency was dependent from the nutritional assessment method: BMI: 3.7%; Chang´s algorithm: 8.8%; SGA: 10.6%; respectively. Nutritional status was weakly associated with CD4+ counts: BMI: ORContingencyTable = 3.69 (p > 0.05); Chang´s algorithm: ORContingencyTable = 2.55 (p = 0.047); and SGA: ORContingencyTable = 1.72 (p > 0.05); respectively. When the study serie was adjusted according anti-retroviral therapy (ARVT), association between CD4+ and nutritional status was as follows: BMI: ORLogisticRegression = 0.367 (p = 0.083); Chang´s Algorithm: ORLogisticRegression = 2.604 (p = 0.050); and SGA: ORLogisticRegression = 1.714 (p = 0.232); respectively. Conclusions: Inception of ARVT modifies the association that might exist between the immune system and nutritional status. Reduction of CD4+ counts in a PHIV/aids was weakly associated with derangement of nutritional indicators. It is likely that body weight excess might be modifying this association: 29.0% of the studied PHIV/aids had BMI values >= 25.0 kg.m-2.

Keywords : HIV/aids; Nutritional status; Global subjective assessment; Body mass index; Chang´s algorithm; CD4+ lymphocytes.

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