Resumo

RODRIGUEZ, J. M. et al. Is there a relationship between gut microbiota, probiotics and body weight modulation?. Nutr. Hosp. [online]. 2013, vol.28, suppl.1, pp.3-12. ISSN 1699-5198.

Introduction: Recent scientific studies show that gut microbiota may play an important role in the modulation of the body weight of the host. Objective: The aim of this article is to present an updated review of the scientific literature dealing with the potential roles of the gut microbiota and probiotics on the body weight of the host, including the predisposition to and prevention of overweight and obesity. Results and conclusions: The use of probiotics in different growth stages, both in human and animal hosts, is usually associated to a beneficial effect to the host's health. Admittedly, benefits associated to growth do not necessarily imply an increase in the adipose tissue or a predisposition to overweight or obesity. At present, the data that link the presence of specific gut microbial groups with obesity are controversial since it is unknown if they represent a cause or a consequence of obesity-associated diets and/or any other factor related to the pathogenesis of this condition. Studies dealing with the modulation of the gut microbiota to prevent or control obesity in the host, including the use of probiotics, are promising. In fact, probiotic intake in the mother-infant context might contribute to the control of the adult body weight by modulating the infant gut microbiota. However, well-designed randomized double-blind placebo-controlled trials are required to demonstrate the efficacy of specific probiotic strains for prevention or treatment of overweight and obesity. In the frame of the current obesity pandemics, use of probiotic strains with scientifically-substantiated properties against obesity risk factors may constitute a future approach, complementary to changes in diet and life style, for the modulation of the body weight.

Palavras-chave : Gut microbiota; Probiotics; Antibiotics; Body weight; Obesity.

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